NB100-91674 Bax antibody

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0.1 mg / €370.00
Please visit the appropriate website of Acris Antibodies or contact your local Distributor to buy this product.

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Rabbit anti Human, Rat Bax

NB100-91674

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  • NB100-91674

Product Description for Bax

Rabbit anti Human, Rat Bax.
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for Bax

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Apoptosis regulator BAX, BCL2-associated X protein, BCL2L4, Bcl-2-like protein 4, Bcl2-L-4
Presentation Purified
Reactivity Hu, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q07812
Genename:
581
Add. information Research Areas: Cancer, Stem Cell Markers
Application ELISA, immunohistochemistry, Western Blot, ELISA, Western Blot and Immunohistochemistry, ELISA 1:10000-1:20000, Western Blot 1:500-1:1000, immunohistochemistry 1:50-1:200,
Background Bcl2 family is a key regulator of apoptosis that functions to either inhibit or promote cell death. Over-expression of members such as Bcl2 and BclxL inhibit the apoptotic process. The Bcl2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with Bcl2 resulting in the enhancement of the anti-apoptotic effect of Bcl2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Bax targets mitochondrial membranes, inducing mitochondrial damage and cell death in a caspase-independent manner. Bad plays a critical role in the Bax-mediated apoptosis pathway by dimerizing with BclxL, causing the displacment of Bax. The displacement of Bax allows apoptosis to proceed. BclxS, a shorter version of BclxL (lacking amino acids 126-188), apparently utilizes a different pathway than Bax to induce cell death. Some research suggests that BclxS uses a novel mechanism for regulating caspase or it may use an alternate cell death effector pathway.
Concentration 1 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format
Purification:
protein A purified
Buffer System:
15mM Sodium Azide
Purity:
protein A purified
State:
Purified
Specificity
Specificity:
Bax (S4) detects endogenous levels of Bax protein.
Species:
Human, Rat
Gene ID 581
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Accessory Products

Proteins and/or Positive Controls

Proteins for Bax (5 products)

Catalog No. Species Pres. Purity   Source  
GTX27987

Bax Control Peptide

Bax n/a
0.1 mg / €230.00
  GeneTex Inc.
H00000581-P01-10

Bax

Bax Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €350.00
  Abnova Taiwan Corp.
H00000581-P01-25

Bax

Bax Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €500.00
  Abnova Taiwan Corp.
H00000581-Q01-10

Bax

Bax Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €350.00
  Abnova Taiwan Corp.
H00000581-Q01-25

Bax

Bax Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €500.00
  Abnova Taiwan Corp.
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