Bcl-2-like 11

Product Description for Bcl-2-like 11

Rabbit anti Human, Mouse, Rat Bcl-2-like 11.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for Bcl-2-like 11

Product Category	Antibodies
Quantity	0.1 ml
Synonyms	BCL2L11, BIM, Bcl2-L-11, Bcl2-interacting mediator of cell death, BimEL, BimL, BimS, Review 004
Presentation	Aff - Purified
Reactivity	Hu, Ms, Rt
Applications	C, WB
Clonality	Polyclonal
Host	Rabbit
Isotype	IgG
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH

Datasheet Extract

Immunogen	Swiss Prot Num: O43521 Immunogen: Internal central amino acids of Human Bim Genename: 10018
Antibody type	Ab
Application	Western blot: 1/1000. 1 μg/mL of this antibody was sufficient for detection of Bim in 20 μg of K562 and A549 cell lysates by colorimetric immunoblot analysis using Goat anti-Rabbit IgG:HRP as the secondary antibody. Immunohistochemistry: 1/50.
Background	Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat (1,2). Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines (1,2).
Concentration	1.0 mg/ml
General Readings	O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 1998 Jan 15;17(2):384-95. PubMed PMID: 9430630. Hsu SY, Lin P, Hsueh AJ. BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol Endocrinol. 1998 Sep;12(9):1432-40. PubMed PMID: 9731710.
Storage	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Format	Purification: Affinity Chromatography Buffer System: PBS Preservatives: 0.02% Sodium Azide State: Liquid purified Ig fraction Aff - Purified
Specificity	Specificity: Detects a 23 kD protein corresponding to the molecular mass of Bim on SDS PAGE immunoblots. Species: Human, Mouse, Rat.
Gene ID	10018
FocusOn and Reviews	Reviews: Antibodies to bcl-2 Protein Family - Product Review 04
Targets	Bcl-2-like 11 antibody

Accessory Products

Proteins and/or Positive Controls

Proteins for Bcl-2-like 11 (7 products)

Catalog No.	Species	Pres.	Source
H00010018-P01-10	Bcl-2-like 11
	Human	Purified		10 µg / €350.00
				Abnova Taiwan Corp.
H00010018-P01-25	Bcl-2-like 11
	Human	Purified		25 µg / €500.00
				Abnova Taiwan Corp.
H00010018-P02	Bcl-2-like 11
	Human	Purified		10 µg / €420.00
				Abnova Taiwan Corp.
H00010018-P02-10	Bcl-2-like 11
	Human	Purified		10 µg / €350.00
				Abnova Taiwan Corp.
H00010018-P02-25	Bcl-2-like 11
	Human	Purified		25 µg / €500.00
				Abnova Taiwan Corp.
H00010018-Q01-10	Bcl-2-like 11
	Human		in vitro transl.	10 µg / €350.00
				Abnova Taiwan Corp.
H00010018-Q01-25	Bcl-2-like 11
	Human		in vitro transl.	25 µg / €500.00
				Abnova Taiwan Corp.

Recommended Secondary Antibodies for Bcl-2-like 11 (6 products)

Catalog No.	Host	Pres.
R1364AP	Rabbit IgG (H+L chain) antibody
	Goat	AP
			Acris Antibodies GmbH
R1364B	Rabbit IgG (H+L chain) antibody
	Goat	Biotin
			Acris Antibodies GmbH
R1364F	Rabbit IgG (H+L chain) antibody
	Goat	FITC
			Acris Antibodies GmbH
R1364HRP	Rabbit IgG (H+L chain) antibody
	Goat	HRP
			Acris Antibodies GmbH
R1364T	Rabbit IgG (H+L chain) antibody
	Goat	TRITC
			Acris Antibodies GmbH
R1427R	Rabbit IgG F(ab)2 Fragment (H+L chain) antibody
	Donkey	PE
			Acris Antibodies GmbH