Product Description for Bcl-2-like 8
Rabbit anti Human, Mouse, Rat Bcl-2-like 8.
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.
Properties for Bcl-2-like 8
| Product Category | Antibodies |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | BAD, BBC6, BCL2L8, Bcl-2-binding component 6, Bcl-2-like protein 8, Bcl-XL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death, Bcl2-L-8, Review 004 |
| Presentation | Aff - Purified |
| Reactivity | Hu, Ms, Rt |
| Applications | P, WB |
| Clonality | Polyclonal |
| Host | Rabbit |
| Shipping to | Not USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | Novus Biologicals Inc. |
Datasheet Extract
| Immunogen |
|
|---|---|
| Antibody type | Ab |
| Add. information | Research Areas: Cancer |
| Application | immunohistochemistry, Western Blot, This antibody is useful for Western Blot and Immunohistochemistry. Western blot analysis of BAD (F130) antibody in extracts from 293 cells treated with Forskolin. Immunohistochemistry analyzes of BAD(F130) antibody in paraffin-embedded human breast carcinoma tissue., Western Blot 1:500-1:1000, immunohistochemistry 1:50-1:200, |
| Background | Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform. |
| Storage | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Format |
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| Specificity |
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| Gene ID | 572 |
| FocusOn and Reviews | |
| Targets |
Accessory Products
Proteins and/or Positive Controls
Proteins for Bcl-2-like 8 (6 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| GTX25335 |
Bcl-2-like 8 pSer112/75 |
||||||
 |
1 packs /
€390.00
|
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| GeneTex Inc. | |||||||
| GTX27985 |
Bcl-2-like 8 Control Peptide |
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|
0.1 mg /
€230.00
|
||||||
| GeneTex Inc. | |||||||
| H00000572-P01-10 |
Bcl-2-like 8 |
||||||
|
Human | in vitro transl. |
10 µg /
€350.00
|
||||
| Abnova Taiwan Corp. | |||||||
| H00000572-P01-25 |
Bcl-2-like 8 |
||||||
|
Human | in vitro transl. |
25 µg /
€500.00
|
||||
| Abnova Taiwan Corp. | |||||||
| H00000572-Q01-10 |
Bcl-2-like 8 |
||||||
|
Human | in vitro transl. |
10 µg /
€350.00
|
||||
| Abnova Taiwan Corp. | |||||||
| H00000572-Q01-25 |
Bcl-2-like 8 |
||||||
|
Human | in vitro transl. |
25 µg /
€500.00
|
||||
| Abnova Taiwan Corp. | |||||||
Positive controls for Bcl-2-like 8 (1 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| NBL1-07900 |
Bad Lysate |
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![Western Blot: Bad Lysate [NBL1-07900] - Western Blot experiments. Left-Control; Right -Over-expression Lysate for BAD.](http://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/Novus/Bad Lysate-Western Blot-NBL1-07900-img0001.jpg) |
0.1 mg /
€370.00
|
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| Novus Biologicals Inc. | |||||||
Recommended Secondary Antibodies for Bcl-2-like 8 (6 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1364AP |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | AP | |||||
| Acris Antibodies GmbH | |||||||
| R1364B |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | Biotin | |||||
| Acris Antibodies GmbH | |||||||
| R1364F |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | FITC | |||||
| Acris Antibodies GmbH | |||||||
| R1364HRP |
Rabbit IgG (H+L chain) antibody |
||||||
|
Goat | HRP | |||||
| Acris Antibodies GmbH | |||||||
| R1364T |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | TRITC | |||||
| Acris Antibodies GmbH | |||||||
| R1427R |
Rabbit IgG F(ab)2 Fragment (H+L chain) antibody |
||||||
|
|
Donkey | PE | |||||
| Acris Antibodies GmbH | |||||||
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