Product Description for Calreticulin
Rabbit anti Canine, Human, Mouse, Primate, Rabbit, Rat Calreticulin.
Presentation: Serum
Product is tested for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot.
Presentation: Serum
Product is tested for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot.
Properties for Calreticulin
| Product Category | Antibodies |
|---|---|
| Quantity | 0.1 ml |
| Synonyms | CALR, CRP55, CRTC, Calregulin, ERp60, FocusOn097, HACBP, grp60 |
| Presentation | Serum |
| Reactivity | Can, Hu, Ms, Prim, Rb, Rt |
| Applications | ICC/IF, IP, WB |
| Clonality | Polyclonal |
| Host | Rabbit |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | Acris Antibodies GmbH |
Datasheet Extract
| Immunogen |
|
|---|---|
| Antibody type | Ab |
| Application | Immunoprecipitation. Immunofluorescence: 1/100, staining of calreticulin in rat brain cortex with SP5414 results in fine granular staining consistent with ER localization. Western Blot: 1/1000, detects an ~60 kDa protein representing calreticulin from rat brain extract. |
| Background | Calreticulin is the major calcium binding protein found in smooth muscle sarcoplasmic reticulum (SR) and non-muscle endoplasmic reticulum (ER) membranes. This protein was originally identified in SR membranes and plays a minor role in calcium storage in skeletal and cardiac muscle SR. Calreticulin is also known as calregulin, CRP55, CaBP3, calsequestrin-like protein and Ro/SS-A antigen. Calreticulin binds calcium with low affinity and high capacity, however it also exhibits a single high affinity binding site. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C-terminus of calreticulin and other resident ER proteins including glucose regulated protein 78 (GRP78), GRP94 and protein disulfide isomerase (PDI). This sequence is responsible for the retention of newly synthesized proteins within the ER lumen. This retention is reported to be mediated by a KDEL receptor. Recent reports indicate that calreticulin can act as a modulator of the regulation of gene transcription by nuclear hormone receptors and may also act as a molecular chaperone. |
| General Readings |
|
| Storage | Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Format |
|
| Specificity |
|
| Gene ID | 811 |
| Targets |
Accessory Products
Proteins and/or Positive Controls
Proteins for Calreticulin (5 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| AR09452PU-L |
Calreticulin (18-417, His-tag) |
||||||
 |
Human | Purified | > 85 % | E. coli |
0.5 mg /
€1,000.00
|
||
| Acris Antibodies GmbH | |||||||
| AR09452PU-N |
Calreticulin (18-417, His-tag) |
||||||
|
Human | Purified | > 85 % | E. coli |
0.1 mg /
€370.00
|
||
| Acris Antibodies GmbH | |||||||
| NBP1-44499 |
Calreticulin |
||||||
![SDS-Page: Calreticulin Protein [NBP1-44499] - Calreticulin, 48.7 kDa (421aa), confirmed by MALDI-TOF with a purity of 85% by SDS - PAGE](http://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/Novus/Calreticulin Protein-SDS-Page-NBP1-44499-img0001.jpg) |
Human | Purified |
0.1 mg /
€390.00
|
||||
| Novus Biologicals Inc. | |||||||
| H00000811-P01-10 |
Calreticulin |
||||||
 |
Human | in vitro transl. |
10 µg /
€350.00
|
||||
| Abnova Taiwan Corp. | |||||||
| H00000811-P01-25 |
Calreticulin |
||||||
|
Human | in vitro transl. |
25 µg /
€500.00
|
||||
| Abnova Taiwan Corp. | |||||||
Positive controls for Calreticulin (1 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| NBL1-08655 |
Calreticulin Lysate |
||||||
![Western Blot: Calreticulin Lysate [NBL1-08655] - Western Blot experiments.
Left-Control; Right -Over-expression Lysate for CALR](http://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/Novus/Calreticulin Lysate-Western Blot-NBL1-08655-img0001.jpg) |
0.1 mg /
€370.00
|
||||||
| Novus Biologicals Inc. | |||||||
Recommended Secondary Antibodies for Calreticulin (6 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1364AP |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | AP | |||||
| Acris Antibodies GmbH | |||||||
| R1364B |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | Biotin | |||||
| Acris Antibodies GmbH | |||||||
| R1364F |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | FITC | |||||
| Acris Antibodies GmbH | |||||||
| R1364HRP |
Rabbit IgG (H+L chain) antibody |
||||||
|
Goat | HRP | |||||
| Acris Antibodies GmbH | |||||||
| R1364T |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | TRITC | |||||
| Acris Antibodies GmbH | |||||||
| R1427R |
Rabbit IgG F(ab)2 Fragment (H+L chain) antibody |
||||||
|
|
Donkey | PE | |||||
| Acris Antibodies GmbH | |||||||
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