Caspase-9

Product Description for Caspase-9

Mouse anti Human, Monkey Caspase-9 2-22.
Presentation: Purified
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for Caspase-9

Product Category	Antibodies
Quantity	50 µg
Synonyms	APAF-3, APAF3, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, CASP-9, CASP9, FocusOn051, ICE-LAP6, ICE-like apoptotic protease 6, MCH6
Presentation	Purified
Reactivity	Hu, Mky
Applications	IP, WB
Clonality	Monoclonal
Clone	2-22
Host	Mouse
Isotype	IgG1
Shipping to	Not USA/Canada
PDF datasheet	View Datasheet
Manufacturer	Novus Biologicals Inc.

Datasheet Extract

Immunogen	Swiss Prot Num: P55211 Immunogen: Recombinant human Caspase-9 protein (prodomain) Genename: 842
Antibody type	Ab
Application	immunoprecipitation, Western Blot, This antibody is useful for Immunoprecipitation, Western blot., immunoprecipitation, Western Blot,
Background	Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase 8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase 3 and Caspase 7, which in turn cause cell collapse. Caspase 9 (also known as ICE like apoptotic protease 6 (ICE LAP6), apoptotic protease Mch6, and apoptotic protease activating factor 3 (Apaf3)) is a member of the peptidase family C14 that contains a CARD domain. This caspase is active as a heterotetramer and has been reported to have two isoforms. ProCaspase 9 has been reported to be approximately 47 kD. This caspase is present in the cytosol and, upon activation, translocates to the mitochondria. Caspase 9 is involved in the caspase activation cascade responsible for apoptosis execution and cleaves/activates Caspase 3 and Caspase 6. Caspase 9 is inhibited by the dominant negative isoform, BclXL, cIAP1, cIAP2, XIAP, and Livin. This caspase becomes activated when recruited to Apaf1/cytochrome c complex, and following cleavage by Apaf1, granzyme B, Caspase 3, possibly Caspase 8 and Caspase 10 into large p37 and small p10 subunits. Caspase 9 intereacts with BIRC7 and has been shown to cleave PARP and vimentin.
Storage	Store at -20C. Avoid freeze-thaw cycles.
Format	Purification: protein G purified Buffer System: Sodium Azide Purity: protein G purified State: Purified
Specificity	Specificity: Caspase-9 (2-22) Species: Human, Primate
Gene ID	842
FocusOn and Reviews	FocusOns: Antibodies to Caspase Family - FocusOn 051
Targets	Caspase-9 antibody

Accessory Products

Proteins and/or Positive Controls

Proteins for Caspase-9 (4 products)

Catalog No.	Species	Source
GTX27885	Caspase-9 (41-56)
			50 µg / €230.00
			GeneTex Inc.
GTX27886	Caspase-9 (299-318)
			50 µg / €230.00
			GeneTex Inc.
H00000842-P01-10	Caspase-9
	Human	in vitro transl.	10 µg / €350.00
			Abnova Taiwan Corp.
H00000842-P01-25	Caspase-9
	Human	in vitro transl.	25 µg / €500.00
			Abnova Taiwan Corp.

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R1253HRP	Mouse IgG (H+L chain) antibody
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R1403R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
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R1405R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
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R1455R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
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