CD19 - AM26006BT-N | acris-antibodies.com

Product Description for CD19

Mouse anti Human CD19 4G7.
Presentation: Biotin
Product is tested for Immunocytochemistry/Immunofluorescence.

Properties for CD19

Product Category	Antibodies
Quantity	0.1 mg
Synonyms	B-cell marker, B-lymphocyte surface antigen B4, Differentiation antigen CD19, Leu-12
Presentation	Biotin
Reactivity	Hu
Applications	ICC/IF
Clonality	Monoclonal
Clone	4G7
Host	Mouse
Isotype	IgG1
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH

Datasheet Extract

Immunogen	Swiss Prot Num: P15391 Immunogen: Human CCL (chronic lymphocytic leukemia) cells Genename: 930
Antibody type	Ab
Application	Indirect immunofluorescence analysis by Flow Cytometry.
Background	CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
Concentration	1.0 mg/ml
General Readings	Muench MO, Roncarolo MG, Namikawa R. Phenotypic and functional evidence for the expression of CD4 by hematopoietic stem cells isolated from human fetal liver. Blood. 1997 Feb 15;89(4):1364-75. PubMed PMID: 9028960. Stockmeyer B, Dechant M, van Egmond M, Tutt AL, Sundarapandiyan K, Graziano RF, et al. Triggering Fc alpha-receptor I (CD89) recruits neutrophils as effector cells for CD20-directed antibody therapy. J Immunol. 2000 Nov 15;165(10):5954-61. PubMed PMID: 11067958. Dubois B, Massacrier C, Caux C. Selective attraction of naive and memory B cells by dendritic cells. J Leukoc Biol. 2001 Oct;70(4):633-41. PubMed PMID: 11590201. Basu S, Lynne CM, Ruiz P, Aballa TC, Ferrell SM, Brackett NL. Cytofluorographic identification of activated T-cell subpopulations in the semen of men with spinal cord injuries. J Androl. 2002 Jul-Aug;23(4):551-6. PubMed PMID: 12065463. Köller M, Zwölfer B, Steiner G, Smolen JS, Scheinecker C. Phenotypic and functional deficiencies of monocyte-derived dendritic cells in systemic lupus erythematosus (SLE) patients. Int Immunol. 2004 Nov;16(11):1595-604. Epub 2004 Sep 20. PubMed PMID: 15381672. Treusch M, Vonthein R, Baur M, Günaydin I, Koch S, Stübiger N, et al. Influence of human recombinant interferon-alpha2a (rhIFN-alpha2a) on altered lymphocyte subpopulations and monocytes in Behcet's disease. Rheumatology (Oxford). 2004 Oct;43(10):1275-82. Epub 2004 Jul 13. PubMed PMID: 15252211. Porcellini S, Vallanti G, Nozza S, Poli G, Lazzarin A, Tambussi G, et al. Improved thymopoietic potential in aviremic HIV infected individuals treated with HAART by intermittent IL-2 administration. AIDS. 2003 Jul 25;17(11):1621-30. PubMed PMID: 12853744. Andersen P, Pedersen MW, Woetmann A, Villingshøj M, Stockhausen MT, Odum N, et al. EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells. Int J Cancer. 2008 Jan 15;122(2):342-9. PubMed PMID: 17918184. Martino V, Tonelli R, Montemurro L, Franzoni M, Marino F, Fazzina R, et al. Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23). Oncol Rep. 2006 Jan;15(1):207-11. PubMed PMID: 16328057.
Storage	Store at 2-8°C. Do not freeze. Shelf life: One year from despatch.
Format	Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin. Biotin Buffer System: PBS Preservatives: 15 mM sodium azide State: Liquid purified Ig fraction
Species Reactivity	Species reactivity (tested): Human
Specificity	Specificity: The mouse monoclonal antibody 4G7 recognizes CD19 (B4), a 95 kDa type I transmembrane glycoprotein of immunoglobulin superfamily, expressed on B lymphocytes and follicular dendritic cells; it is lost on plasma cells.
Gene ID	930
Targets	CD19 antibody

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