AM26379PU-N CD209 / DC-SIGN antibody

Swiss Prot Num:

Q9NNX6

Immunogen:

CD209-His-tagged fusion protein

Flow Cytometry.
Immunohistochemistry.
Immunocytochemistry.

• Khoo US, Chan KY, Chan VS, Lin CL: DC-SIGN and L-SIGN: the SIGNs for infection. J Mol Med. 2008 Aug;86(8):861-74.
• van Kooyk Y, Geijtenbeek TB. A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions. Immunol Rev. 2002 Aug;186:47-56. PubMed PMID: 12234361.
• Geijtenbeek TB, Engering A, Van Kooyk Y. DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J Leukoc Biol. 2002 Jun;71(6):921-31. PubMed PMID: 12050176.
• Ryan EJ, Marshall AJ, Magaletti D, Floyd H, Draves KE, Olson NE, et al. Dendritic cell-associated lectin-1: a novel dendritic cell-associated, C-type lectin-like molecule enhances T cell secretion of IL-4. J Immunol. 2002 Nov 15;169(10):5638-48. PubMed PMID: 12421943.

Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Purification:

Protein-A affinity chromatograpy ( > 95% by SDS-PAGE)

Buffer System:

PBS, approx. pH 7.4

Preservatives:

15 mM sodium azide

State:

Liquid Ig fraction
Aff - Purified

Species reactivity (tested):

Human

Specificity:

The mouse monoclonal antibody UW60.1 recognizes CD209 (DC-SIGN), a 44 kDa transmembrane receptor expressed on the surface of dendritic cells and macrophages.