AM26171FC-N CD23 antibody

Swiss Prot Num:

P06734

Immunogen:

EBV-transformed human cells

Flow Cytometry analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension.
The content of a vial (0.4 ml) is sufficient for 100 tests.

• Ling NR, Stevenson FK, Brown B. Urinary excretion of CD23 antigen in normal individuals and patients with chronic lymphocytic leukaemia (CLL) Clin Exp Immunol. 1991 Dec;86(3):360-6. PubMed PMID: 1721010.
• Yamaoka KA, Arock M, Issaly F, Dugas N, Le Goff L, Kolb JP. Granulocyte macrophage colony stimulating factor induces Fc epsilon RII/CD23 expression on normal human polymorphonuclear neutrophils. Int Immunol. 1996 Apr;8(4):479-90. PubMed PMID: 8722638.
• Belleau JT, Gandhi RK, McPherson HM, Lew DB: Research upregulation of CD23 (FcepsilonRII) expression in human airway smooth muscle cells (huASMC) in response to IL-4, GM-CSF, and IL-4/GM-CSF. Clin Mol Allergy. 2005 May 20;3:6.
• Byrd JC, O'Brien S, Flinn IW, Kipps TJ, Weiss M, Rai K, Lin TS, Woodworth J, Wynne D, Reid J, Molina A, Leigh B, Harris S: Phase 1 study of lumiliximab with detailed pharmacokinetic and pharmacodynamic measurements in patients with relapsed or refractory chronic lymphocytic leukemia. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4448-55.
• Rumi C, Rutella S, Leone G, Bonini S. Fc-RII/CD23 receptor on circulating human eosinophils. Blood. 1998 Apr 1;91(7):2621-2. PubMed PMID: 9516167.

Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.

Label:

Conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use.
FITC

Buffer System:

PBS

Preservatives:

15 mM sodium azide

Stabilizers:

0.2% (w/v) high-grade protease free Bovine Serum Albumin

State:

Liquid purified Ig fraction

Species reactivity (tested):

Human

Specificity:

The mouse monoclonal antibody EBVCS-5 recognizes an epitope located in the stalk region of human low affinity IgE receptor (CD23) between the 37 and 25 kDa cleavage sites.