CD283 / TLR3

Product Description for CD283 / TLR3

Mouse anti Canine, Human, Mouse CD283 / TLR3 40C1285.6.
Presentation: Alexa Fluor 647
Product is tested for Immunocytochemistry/Immunofluorescence, Flow Cytometry.

Properties for CD283 / TLR3

Product Category	Antibodies
Quantity	0.1 mg
Synonyms	FocusOn004, Toll-like receptor 3
Presentation	Alexa Fluor 647
Reactivity	Can, Hu, Ms
Applications	F, ICC/IF
Clonality	Monoclonal
Clone	40C1285.6
Host	Mouse
Isotype	IgG1
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH

Datasheet Extract

Immunogen	Swiss Prot Num: O15455 Immunogen: KLH-conjugated synthetic peptide of human TLR3
Antibody type	Ab
Application	Flow cytometry (Cell Surface). Flow cytometry (Intracellular): 0.5-1.0 µg/10e6 cells. Immunoflourescence / Immunocytochemistry.
Background	The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1) and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described (3). TLR3 cDNA codes for a protein with approximate molecular weight of 120 kDa (4). TLR3 has a restricted expression pattern being expressed in dendritic cells (DC) (4-6). TLR3 mRNA expression was detected by in situ hybridization in DC and lymph nodes (6). The expression of TLR3 in a single cell type may indicate a specific role for this molecule in a restricted setting.
Concentration	0.5 mg/ml
General Readings	Muzio M, Natoli G, Saccani S, Levrero M, and Mantovani A. J. Exp. Med. 187: 2097-2101 (1998). Medzhitov R and Janeway CA. Cell 91: 295-298 (1997). Chuang TH and Ulevitch RJ. Biochim. Biophys. Acta 1518 (1-2): 157-161 (2001) Rock FL., Hardiman G., Timans JC., Kastelein RA. and Bazan JF. Proc. Natl. Acad. Sci. U.S.A. 95 (2), 588-593 (1998). Muzio M, Polentarutti N, Bosisio D, Prahladan MK, Mantovani A. Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes. J Leukoc Biol. 2000 Apr;67(4):450-6. PubMed PMID: 10770275. Muzio M, Bosisio D, Polentarutti N, D'amico G, Stoppacciaro A, Mancinelli R, et al. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J Immunol. 2000 Jun 1;164(11):5998-6004. PubMed PMID: 10820283.
Storage	Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Shelf life: one year from despatch.
Format	Label: Alexa Fluor 647 Purification: Protein G chromatography Buffer System: PBS containing 0.05% BSA and 0.05% sodium azide State: Liquid Ig fraction
Species Reactivity	Species reactivity (tested): Human, mouse, dog
Specificity	Specificity: This antibody detects CD283 / TLR3.
FocusOn and Reviews	FocusOns: Antibodies to Toll-Like Receptor (TLR) Family - FocusOn 004
Targets	CD283 / TLR3 antibody

Accessory Products

Proteins and/or Positive Controls

Proteins for CD283 / TLR3 (3 products)

Catalog No.	Species	Source
H00007098-G01	CD283 / TLR3
	Human		10 µg / €530.00
			Abnova Taiwan Corp.
H00007098-Q01-10	CD283 / TLR3
	Human	in vitro transl.	10 µg / €350.00
			Abnova Taiwan Corp.
H00007098-Q01-25	CD283 / TLR3
	Human	in vitro transl.	25 µg / €500.00
			Abnova Taiwan Corp.

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