CD284 / TLR4 - SM1827AF647 | acris-antibodies.com

Product Description for CD284 / TLR4

Rat anti Mouse CD284 / TLR4 MTS510.
Presentation: Alexa Fluor 647
Product is tested for Flow Cytometry.

Properties for CD284 / TLR4

Product Category	Antibodies
Quantity	0.1 mg
Synonyms	FocusOn004, Toll-like receptor 4
Presentation	Alexa Fluor 647
Reactivity	Ms
Applications	F
Clonality	Monoclonal
Clone	MTS510
Host	Rat
Isotype	IgG2a
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH

Datasheet Extract

Immunogen	Swiss Prot Num: Q9QUK6 Immunogen: Ba/F3 cell line expressing mouse TLR4 and MD-2 (Akashi et al. 2000) Genename: 21898
Antibody type	Ab
Application	Flow cytometry (Cell surface): 0.5-2.0 µg/10e6 cells. Recommended positive control: RAW, mouse peritoneal cells.
Background	The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). Among this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling (4,5). The mouse TLR4 cDNA codes for a protein consisting of 835 amino acids with approximate molecular weight of 90 kDa (6).
Concentration	0.5 mg/ml
General Readings	Akashi S, Shimazu R, Ogata H, Nagai Y, Takeda K, Kimoto M, Miyake K. J Immunol 164(7):3471-5 (2000). Muzio M, Natoli G, Saccani S, Levrero M, and Mantovani A. J. Exp. Med. 187: 2097-2101 (1998). Medzhitov R and Janeway CA. Cell 91: 295-298 (1997). Chuang TH and Ulevitch RJ. Biochim. Biophys. Acta 1518 (1-2): 157-161 (2001). Takeuchi O., Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa K, Takeda K and Akira S. Immunity 11: 443 (1999). Poltorak A, Riccardi-Castagnoli P, Citterio S, and Butler B. Proc. Natl. Acad. Sci USA 97: 2163-2167 (2000). Medzhitov R, Preston-Hurlburt P and Janeway CA Jr. Nature 388 (6640), 394-397 (1997).
Storage	Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Shelf life: one year from despatch.
Format	Label: Alexa Fluor® 647 Alexa Fluor 647 Purification: Protein G chromatography Buffer System: PBS containing 0.05% BSA and 0.05% sodium azide State: Liquid Ig fraction
Species Reactivity	Species reactivity (tested): Mouse
Specificity	Specificity: This antibody detcts CD284 / TLR4.
Gene ID	21898
FocusOn and Reviews	FocusOns: Antibodies to Toll-Like Receptor (TLR) Family - FocusOn 004
Targets	CD284 / TLR4 antibody

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