AM26375PU-N Collagen Type II antibody

Swiss Prot Num:

P02458

Genename:

1280

•  Nandakumar, K et al; Collagen Type II-specific monoclonal antibody-induced arthritis in mice. Description of the disease and the influence of age, sex and genes. Am J Pathol 2003, 163: 1827.
• Nandakumar KS, Bäcklund J, Vestberg M, Holmdahl R. Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells. Arthritis Res Ther. 2004;6(6):R544-50. Epub 2004 Sep 23. PubMed PMID: 15535832.

Store at 2 - 8 °C.
Shelf life: one year from despatch.

Purification:

Protein G

Buffer System:

PBS

Stabilizers:

0.1% bovine serum albumin

State:

Liquid 0.2 µm filtered Ig fraction
Purified

Species reactivity (tested):

Human, mouse, rat chicken, bovine

Specificity:

The monoclonal antibody CIICI reacts with the C1 epitope (triple helical position 358-364) of collagen type II.
It has been shown to induce CAIA in naïve mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody M2139, binding to the J1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity. The monoclonal antibody CIIC1 is cross reactive with rat, bovine, chicken and human CII.