DM127-05 Cytokeratin 17 antibody

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0.5 ml / €270.00
Please visit the appropriate website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human, Rat Cytokeratin 17 Ks17.E3

Product Description for Cytokeratin 17

Mouse anti Human, Rat Cytokeratin 17 Ks17.E3.
Presentation: Supernatant
Product is tested for Frozen Sections, Western blot / Immunoblot, Paraffin Sections.

Properties for Cytokeratin 17

Product Category Antibodies
Quantity 0.5 ml
Synonyms CK17, Cytokeratin-17, K17, KRT17, Keratin 17, Keratin type I cytoskeletal 17, Keratin-17, Review 009
Presentation Supernatant
Reactivity Hu, Rt
Applications C, P, WB
Clonality Monoclonal
Clone Ks17.E3
Host Mouse
Isotype IgG2b
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH

Datasheet Extract

Immunogen
Swiss Prot Num:
Q04695
Immunogen:
Cytoskeletal fraction of rat colon epithelium.
Genename:
3872
Antibody type Ab
Application Immunohistochemistry on Paraffin Embedded Sections: diluted of 1/25-1/50 in an ABC method (30 minutes at room temperature).
Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining.
Positive Control: Skin.
Background Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
Product Citations
  • Hachiya A, Sriwiriyanont P, Fujimura T, Ohuchi A, Kitahara T, Takema Y, et al. Mechanistic effects of long-term ultraviolet B irradiation induce epidermal and dermal changes in human skin xenografts. Am J Pathol. 2009 Feb;174(2):401-13. doi: 10.2353/ajpath.2009.070500. Epub 2009 Jan 15. PubMed PMID: 19147832.
General Readings
  • Troyanovsky et al. J Cell Sci 93: 419, 1989.
  • Smedts et al. Am J Pathol 140: 601, 1992.
  • Smedts et al. Am J Pathol 141: 497, 1992.
  • Wetzels et al. Histopathol 20: 295, 1992.
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
State:
Liquid Supernatant containing Sodium Azide as preservative.
Supernatant
Specificity
Specificity:
This antibody is specific to 46 kD Cytokeratin protein designated Cytokeratin 17. It reacts with basal cells in complex epithelia and reacts strongly with squamous cell carcinomas.
Cellular Localization: Cytoplasmic
Species:
Human.
Gene ID 3872
FocusOn and Reviews
Reviews:
Targets

Accessory Products

Proteins and/or Positive Controls

Proteins for Cytokeratin 17 (2 products)

Catalog No. Species Pres. Purity   Source  
H00003872-P01-10

Cytokeratin 17 (1-433)

Cytokeratin 17 Human in vitro transl.
10 µg / €350.00
  Abnova Taiwan Corp.
H00003872-P01-25

Cytokeratin 17 (1-433)

Cytokeratin 17 Human in vitro transl.
25 µg / €500.00
  Abnova Taiwan Corp.

Positive controls for Cytokeratin 17 (1 products)

Catalog No. Species Pres. Purity   Source  
H00003872-T01

Cytokeratin-17 (KRT17) Lysate(Denatured)

Cytokeratin-17 (KRT17) Lysate(Denatured)
0.1 ml / €240.00
  Abnova Taiwan Corp.