GABAA Receptor alpha 6 - AP08658PU-N | acris-antibodies.com

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Product Description for GABAA Receptor alpha 6

Rabbit anti Bovine, Human, Mouse, Rat GABAA Receptor alpha 6.
Presentation: Aff - Purified
Product is tested for Dot blot, Western blot / Immunoblot.

Properties for GABAA Receptor alpha 6

Product Category	Antibodies
Quantity	0.1 ml
Synonyms	GABRA-6, GABRA6, Gamma-Aminobutyric Acid Receptor subunit Alpha-6, Review 022
Presentation	Aff - Purified
Reactivity	Bov, Hu, Ms, Rt
Applications	Dot, WB
Clonality	Polyclonal
Host	Rabbit
Isotype	IgG
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH
Material safety datasheet	MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen	Swiss Prot Num: P30191 Immunogen: Fusion protein from the cytoplasmic loop of the Alpha-6 subunit of Rat GABAA Receptor. Genename: 29708
Antibody type	Ab
Application	Dot Blot: 1/1000. Western Blot: 1/1000.
Background	Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six Alpha's, four Beta's and four Gamma's, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for Alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a Gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different Alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).
General Readings	McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, et al. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. Nat Neurosci. 2000 Jun;3(6):587-92. PubMed PMID: 10816315. Mehta AK, Ticku MK (1998) Prevalence of the GABAA receptor assemblies containing Alpha-1 subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: Lack of modulation by chronic ethanol administration. Mol Brain Res 67:194-199. Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, et al. Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit. Biochem Pharmacol. 2004 Oct 15;68(8):1621-9. PubMed PMID: 15451405. Olsen RW, Tobin AJ (1990) Molecular biology of GABAA receptors. FASEB 4:1469-1480. Pöltl A, Hauer B, Fuchs K, Tretter V, Sieghart W. Subunit composition and quantitative importance of GABA(A) receptor subtypes in the cerebellum of mouse and rat. J Neurochem. 2003 Dec;87(6):1444-55. PubMed PMID: 14713300. Whiting PJ, Bonnert TP, McKernan RM, Farrar S, Le Bourdellès B, Heavens RP, et al. Molecular and functional diversity of the expanding GABA-A receptor gene family. Ann N Y Acad Sci. 1999 Apr 30;868:645-53. PubMed PMID: 10414349.
Storage	Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Format	Purification: Affinity Chromatography. Buffer System: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% Glycerol. State: Liquid purified Ig fraction. Aff - Purified
Specificity	Specificity: Specific for the ~57k Alpha-6 subunit of the GABAA Receptor in Western blots of Rat brain membrane fractions. Also recognizes the alpha-6 subunit of GABAA-R in Bovine, Human amnd Mouse brain extracts. Does not recognizes GABAA-R subunits as reactivity is eliminated in alpha-6 knockout brain. Species: Rat, Mouse, Human, Bovine.
Gene ID	29708
FocusOn and Reviews	Reviews: GABA A Receptor Regulator of Excitability and Drug Ta - Product Review 22
Targets	GABAA Receptor alpha 6 antibody

Accessory Products

Recommended Secondary Antibodies for GABAA Receptor alpha 6 (6 products)

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R1364AP	Rabbit IgG (H+L chain) antibody
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R1364F	Rabbit IgG (H+L chain) antibody
	Goat		FITC
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R1364HRP	Rabbit IgG (H+L chain) antibody
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R1364T	Rabbit IgG (H+L chain) antibody
	Goat		TRITC
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R1427R	Rabbit IgG F(ab)2 Fragment (H+L chain) antibody
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