Product Description for HSP90AB1 / HSP90 beta
Rabbit anti Human, Mouse, Rat HSP90AB1 / HSP90 beta.
Presentation: Serum
Product is tested for Immunocytochemistry/Immunofluorescence, Frozen Sections, Enzyme Immunoassay, Immunoprecipitation, Western blot / Immunoblot.
Presentation: Serum
Product is tested for Immunocytochemistry/Immunofluorescence, Frozen Sections, Enzyme Immunoassay, Immunoprecipitation, Western blot / Immunoblot.
Properties for HSP90AB1 / HSP90 beta
| Product Category | Antibodies |
|---|---|
| Quantity | 25 µl |
| Synonyms | HSP84, HSP90B, HSPC2, HSPCB, Heat shock 84 kDa, Heat shock protein HSP 90-beta, Review 003 |
| Presentation | Serum |
| Reactivity | Hu, Ms, Rt |
| Applications | C, E, ICC/IF, IP, WB |
| Clonality | Polyclonal |
| Host | Rabbit |
| Isotype | IgG |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | Acris Antibodies GmbH |
Datasheet Extract
| Immunogen |
|
|---|---|
| Antibody type | Ab |
| Application | ELISA. Western blot (1): 1/20000-1/40000 (ECL). A 1/4000 dilution of this antibody was sufficient for detection of HSP90 in 20 μg of HeLa cell lysate by ECL immunoblot analysis. Immunoprecipitation. Immunofluorescence. Immunohistochemistry. |
| Background | Hsp90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, hsp90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex (1-4). Despite its label of being a heat-shock protein, hsp90 is one of the most highly expressed proteins in unstressed cells (1–2% of cytosolic protein). It carries out a number of housekeeping functions – including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the hsp90-regulated proteins that have been discovered to date are involved in cell signaling (5-6). The number of proteins now know to interact with Hsp90 is about 100. Target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase.5. When bound to ATP, Hsp90 interacts with co-chaperones Cdc37, p23, and an assortment of immunophilin-like proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation. In most cases, hsp90-interacting proteins have been shown to co-precipitate with hsp90 when carrying out immunoadsorption studies, and to exist in cytosolic heterocomplexes with it. In a number of cases, variations in hsp90 expression or hsp90 mutation has been shown to degrade signaling function via the protein or to impair a specific function of the protein (such as steroid binding, kinase activity) in vivo. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit hsp90 function (7). |
| General Readings |
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| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
| Format |
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| Specificity |
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| Gene ID | 3326 |
| FocusOn and Reviews | |
| Targets |
Accessory Products
Proteins and/or Positive Controls
Proteins for HSP90AB1 / HSP90 beta (2 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| H00003326-P01-10 |
HSP90AB1 / HSP90 beta |
||||||
 |
Human | Purified |
10 µg /
€350.00
|
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| Abnova Taiwan Corp. | |||||||
| H00003326-P01-25 |
HSP90AB1 / HSP90 beta |
||||||
|
Human | Purified |
25 µg /
€500.00
|
||||
| Abnova Taiwan Corp. | |||||||
Positive controls for HSP90AB1 / HSP90 beta (1 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| NBL1-11745 |
Hsp90B Lysate |
||||||
![Western Blot: Hsp90B Lysate [NBL1-11745] - Western Blot experiments.
Left-Control; Right -Over-expression Lysate for HSP90AB1](http://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/Novus/Hsp90B Lysate-Western Blot-NBL1-11745-img0001.jpg) |
0.1 mg /
€370.00
|
||||||
| Novus Biologicals Inc. | |||||||
Recommended Secondary Antibodies for HSP90AB1 / HSP90 beta (6 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1364AP |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | AP | |||||
| Acris Antibodies GmbH | |||||||
| R1364B |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | Biotin | |||||
| Acris Antibodies GmbH | |||||||
| R1364F |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | FITC | |||||
| Acris Antibodies GmbH | |||||||
| R1364HRP |
Rabbit IgG (H+L chain) antibody |
||||||
|
Goat | HRP | |||||
| Acris Antibodies GmbH | |||||||
| R1364T |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | TRITC | |||||
| Acris Antibodies GmbH | |||||||
| R1427R |
Rabbit IgG F(ab)2 Fragment (H+L chain) antibody |
||||||
|
|
Donkey | PE | |||||
| Acris Antibodies GmbH | |||||||
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