KLK6 / Kallikrein-6 (C-term) - AP09594PU-N

Product Description for KLK6 / Kallikrein-6

Goat anti Bovine, Mouse, Rat KLK6 / Kallikrein-6.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for KLK6 / Kallikrein-6

Product Category	Antibodies
Quantity	0.1 mg
Synonyms	FocusOn006, FocusOn130, Neurosin, PRSS18, PRSS9, Protease M, SP59, Serine protease 18, Serine protease 9, Zyme
Presentation	Aff - Purified
Reactivity	Bov, Ms, Rt
Applications	E, WB
Clonality	Polyclonal
Host	Goat
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH

Datasheet Extract

Immunogen	Swiss Prot Num: Q92876 Immunogen: Peptide from the C-Terminus of Mouse Kallikrein-6 according to NP_035307.1. AA Sequence: `KEKPGVYTDVCTHIR` Genename: 5653
Property	C-term
Antibody type	Ab
Add. information	Related Products: AP13373PU-N: Rabbit anti-Human Kallikrein-6 Antibody (N-term) AP13374PU-N: Rabbit anti-Human Kallikrein-6 Antibody (Center)
Application	Peptide ELISA: Kallikrein-6 Antibody Detection limit dilution 1/16000. Western blot: 1-3 µg/ml. Approx 22kDa band observed in Mouse Liver lysates (calculated MW of 27.5kDa according to NP_035307.1). An additional band of unknown identity was also consistently observed at 48kDa. Both bands were successfully blocked by incubation with the immunising peptide.
Background	Tissue kallikreins are a family of extracellular serine proteases consisting of 15 members (1, 2). The genes of this family aligned in tandem on chromosome 19q13.4 represent the largest contiguous group of proteases within the human genome. Tissue kallikreins have attracted great interest as potential biomarkers for various cancers, including prostate, ovarian, breast, testicular, and lung (2, 3). Human Kallikrein 6 (hKLK6) is a member of tissue kallikrein family observed in breast and brain tissues, colon carcinoma cells, and oligodedrocytes (1 3). Known protein substrates of hKLK6 are myelin basic protein, the precursor of the Abeta amyloid peptide, and plasminogen. Its physiological functions may include the participation in demyelination processes as well as in the progression of inflammatory disease of the CNS. The level of hKLK6 is reduced in brain extracts of Alzheimer patients and increased in serum of patients with ovarian cancer.
Concentration	0.5 mg/ml
General Readings	1. Emami, N. and E.P. Diamandis (2007) Clin Chim Acta 381:78. 2. Borgoño, C.A. and E.P. Diamandis (2004) Nat. Rev. Cancer, 4:876. 3. Paliouras, M. et al. (2007) Cancer Lett. 249:61. 4. Iwata A, Maruyama M, Akagi T, Hashikawa T, Kanazawa I, Tsuji S, Nukina N, Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. Hum Mol Genet. 2003 Oct 15;12(20):2625-35. Epub 2003 Aug 19. PMID: 12928483
Storage	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Format	Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide Buffer System: Tris saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer State: Liquid purified Ig fraction Aff - Purified
Species Reactivity	Species reactivity (expected): Rat and Cow. Species reactivity (tested): Mouse.
Gene ID	5653
FocusOn and Reviews	FocusOns: Antibodies to Kallikrein Family - FocusOn 006 Antibodies for Alzheimer’s Disease - FocusOn 130
Targets	KLK6 / Kallikrein-6 antibody

Accessory Products

Proteins and/or Positive Controls

Proteins for KLK6 / Kallikrein-6 (7 products)

Catalog No.	Species	Pres.	Purity	Source
NBP1-74344	KLK6 / Kallikrein-6
	Human	Purified			0.2 mg / €320.00
					Novus Biologicals Inc.
NBP1-74345	KLK6 / Kallikrein-6
	Human	Purified			0.2 mg / €320.00
					Novus Biologicals Inc.
H00005653-P01-10	KLK6 / Kallikrein-6
	Human	Purified			10 µg / €350.00
					Abnova Taiwan Corp.
H00005653-P01-25	KLK6 / Kallikrein-6
	Human	Purified			25 µg / €500.00
					Abnova Taiwan Corp.
H00005653-Q01-10	KLK6 / Kallikrein-6
	Human			in vitro transl.	10 µg / €350.00
					Abnova Taiwan Corp.
H00005653-Q01-25	KLK6 / Kallikrein-6
	Human			in vitro transl.	25 µg / €500.00
					Abnova Taiwan Corp.
LF-P0055	KLK6 / Kallikrein-6
	Human		> 85 %	E. coli	0.5 mg / €270.00
					Young In Frontier Co. Ltd.

Positive controls for KLK6 / Kallikrein-6 (2 products)

Catalog No.	Species
NBL1-12354	Kallikrein 6 Lysate
		0.1 mg / €370.00
		Novus Biologicals Inc.
NBL1-12355	Kallikrein 6 Lysate
		0.1 mg / €370.00
		Novus Biologicals Inc.

Recommended Secondary Antibodies for KLK6 / Kallikrein-6 (6 products)

Catalog No.	Host	Pres.
R1317AP	Goat IgG (H+L chain) antibody
	Rabbit	AP
			Acris Antibodies GmbH
R1317B	Goat IgG (H+L chain) antibody
	Rabbit	Biotin
			Acris Antibodies GmbH
R1317F	Goat IgG (H+L chain) antibody
	Rabbit	FITC
			Acris Antibodies GmbH
R1317HRP	Goat IgG (H+L chain) antibody
	Rabbit	HRP
			Acris Antibodies GmbH
R1317T	Goat IgG (H+L chain) antibody
	Rabbit	TRITC
			Acris Antibodies GmbH
R1416R	Goat IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Donkey	PE
			Acris Antibodies GmbH