MAPT / TAU pThr181 (177-187) - AM26411PU-L

Product Description for MAPT / TAU

Mouse anti Human, Mouse MAPT / TAU 1A4.
Properties: pThr181 (177-187)
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for MAPT / TAU

Product Category	Antibodies
Quantity	0.5 mg
Synonyms	FocusOn130, MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau
Presentation	Aff - Purified
Reactivity	Hu, Ms
Applications	WB
Clonality	Monoclonal
Clone	1A4
Host	Mouse
Isotype	IgG2a
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH
Material safety datasheet	MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen	Swiss Prot Num: P10636 Immunogen: KLH conjugated with a short peptide corresponding to the amino acid sequence 177-187 on the phosphorylated Tau protein AA Sequence: `Ala-Pro-Lys-Thr(p)-Pro-Pro-Ser-Ser-Gly-Glu-Cys`
Property	177-187, pThr181
Antibody type	Ab
Application	Western blot
Background	Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.
Storage	Store at -20 °C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Format	Purification: Protein G affinity purified Buffer System: 0.01M PBS pH7.2 State: Lyophilized Ig fraction Aff - Purified Reconstitution: Double distillated water is recommended to reconstitute the antibody.
Species Reactivity	Species reactivity (tested): Human, mouse
Specificity	Specificity: This antibody recognizes the aa177-187 on phosphorylated Tau protein and its KLH conjugate, but not recognizes KLH alone. The antibody detected a 46kD band in mouse brain tissue lysate.
Targets	MAPT / TAU antibody

Accessory Products

Recommended Secondary Antibodies for MAPT / TAU (8 products)

Catalog No.	Host	Pres.
R1253AP	Mouse IgG (H+L chain) antibody
	Rabbit	AP
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R1253B	Mouse IgG (H+L chain) antibody
	Rabbit	Biotin
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R1253F	Mouse IgG (H+L chain) antibody
	Rabbit	FITC
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R1253HRP	Mouse IgG (H+L chain) antibody
	Rabbit	HRP
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R1253TR	Mouse IgG (H+L chain) antibody
	Rabbit	Texas Red
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R1403R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Rabbit	PE
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R1405R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Goat	PE
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R1455R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Donkey	PE
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