Product Description for MMP-11
Rabbit anti Human, Mouse, Rat MMP-11 EP1259-1.
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Paraffin Sections, Western blot / Immunoblot.
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Paraffin Sections, Western blot / Immunoblot.
Properties for MMP-11
| Product Category | Antibodies |
|---|---|
| Quantity | 0.1 ml |
| Synonyms | MMP11, Matrix metalloproteinase-11, Review 001, SL-3, ST3, STMY3, Stromelysin-3 |
| Presentation | Aff - Purified |
| Reactivity | Hu, Ms, Rt |
| Applications | ICC/IF, P, WB |
| Clonality | Monoclonal |
| Clone | EP1259-1 |
| Host | Rabbit |
| Isotype | IgG |
| Shipping to | Not USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | Novus Biologicals Inc. |
Datasheet Extract
| Immunogen |
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|---|---|
| Antibody type | Ab |
| Add. information | Research Areas: Cancer |
| Application | Immunocytochemistry, immunohistochemistry, Western Blot, Immunohistochemistry, Western Blot and Immunocytochemistry, immunohistochemistry 1:100 ? 250, Western Blot 1:500, Immunocytochemistry 1:100 ? 250 |
| Background | The matrix metalloproteinases are a tightly regulated family of enzymes that degrade extracellular matrix and basement membrane components. Recent evidence suggests that these proteases and their specific inhibitors play important roles in normal developmental processes and in pathological conditions (1). MMP-11 (stromelysin-3), a new member of the matrix metalloproteinase family, is expressed in tissues undergoing the active remodeling associated with embryonic development, wound healing and tumor invasion. But like all other members of the matrix metalloproteinase gene family, stromelysin-3 is synthesized as an inactive precursor that must be processed to its mature form in order to express enzymic activity (2). MMP-11, like an inflammatory mediator, may exert a chemotactic influence on macrophages which aggregate in the mesangium; MMP-11 is not likely to have a parallel mitogenic or antifibrotic effect in diseased glomeruli (3). |
| General Readings | 1. Pei D, et al. Nature 375(6528):244-7, 1995. 2. Matrisian LM, et al. Trends Genet 6(4):121-5, 1990. 3. Nakopoulou L, et al. Nephrol Dial Transplant 22(1):109-17, 4. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Format |
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| Specificity |
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| Gene ID | 4320 |
| FocusOn and Reviews | |
| Targets |
Accessory Products
Recommended Secondary Antibodies for MMP-11 (6 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1364AP |
Rabbit IgG (H+L chain) antibody |
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|
Goat | AP | |||||
| Acris Antibodies GmbH | |||||||
| R1364B |
Rabbit IgG (H+L chain) antibody |
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|
|
Goat | Biotin | |||||
| Acris Antibodies GmbH | |||||||
| R1364F |
Rabbit IgG (H+L chain) antibody |
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|
|
Goat | FITC | |||||
| Acris Antibodies GmbH | |||||||
| R1364HRP |
Rabbit IgG (H+L chain) antibody |
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|
Goat | HRP | |||||
| Acris Antibodies GmbH | |||||||
| R1364T |
Rabbit IgG (H+L chain) antibody |
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|
|
Goat | TRITC | |||||
| Acris Antibodies GmbH | |||||||
| R1427R |
Rabbit IgG F(ab)2 Fragment (H+L chain) antibody |
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|
|
Donkey | PE | |||||
| Acris Antibodies GmbH | |||||||
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