Product Description for MMP-12
Rabbit anti Human, Mouse, Rat MMP-12 EP1261Y.
Presentation: Aff - Purified
Product is tested for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Paraffin Sections, Immunoprecipitation, Western blot / Immunoblot.
Presentation: Aff - Purified
Product is tested for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Paraffin Sections, Immunoprecipitation, Western blot / Immunoblot.
Properties for MMP-12
| Product Category | Antibodies |
|---|---|
| Quantity | 0.1 ml |
| Synonyms | HME, ME, MMP12, Macrophage elastase, Macrophage metalloelastase, Matrix metalloproteinase-12, Review 001 |
| Presentation | Aff - Purified |
| Reactivity | Hu, Ms, Rt |
| Applications | F, ICC/IF, IP, P, WB |
| Clonality | Monoclonal |
| Clone | EP1261Y |
| Host | Rabbit |
| Isotype | IgG |
| Shipping to | Not USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | Novus Biologicals Inc. |
Datasheet Extract
| Immunogen |
|
|---|---|
| Antibody type | Ab |
| Application | flow cytometry / FACS analysis, Immunocytochemistry, immunohistochemistry, immunoprecipitation, Western Blot, This antibody is useful for FACS, immunohistochemistry, immunoprecipitation, Western Blot and Immunocytochemistry., flow cytometry / FACS analysis 1:10, immunohistochemistry 1:100-1:250, immunoprecipitation 1:30, Western Blot 1:2000, Immunocytochemistry 1:100-1:250 |
| Background | Human macrophage elastase (MMP-12) is a member of the family of matrix metalloproteinases (MMPs) that plays, like other members of the family, an important role in inflammatory processes contributing to tissue remodeling and destruction. In particular, a prominent role of MMP-12 in the destruction of elastin in the lung alveolar wall and the pathogenesis of emphysema has been suggested. It is therefore an attractive therapeutic target (1). MMP-12) expressed mainly in alveolar macrophages has been identified in the mouse lung as the main destructive agent associated with cigarette smoking, which gives rise to emphysema, both directly via elastin degradation and indirectly by disturbing the proteinase/antiproteinase balance via inactivation of the alpha1-proteinase inhibitor (alpha1-PI), the antagonist of the leukocyte elastase (2). Because elastin represents a critical component of aortic wall structure and a matrix substrate for metalloelastases, MMP-12 may have a direct and singular role in the pathogenesis of aortic aneurysms (3). |
| General Readings |
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| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Format |
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| Specificity |
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| Gene ID | 4321 |
| FocusOn and Reviews | |
| Targets |
Accessory Products
Proteins and/or Positive Controls
Proteins for MMP-12 (5 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| H00004321-P01-10 |
MMP-12 |
||||||
 |
Human | Purified |
10 µg /
€350.00
|
||||
| Abnova Taiwan Corp. | |||||||
| H00004321-P01-25 |
MMP-12 |
||||||
|
Human | Purified |
25 µg /
€500.00
|
||||
| Abnova Taiwan Corp. | |||||||
| H00004321-Q01-10 |
MMP-12 |
||||||
|
Human | Purified |
10 µg /
€350.00
|
||||
| Abnova Taiwan Corp. | |||||||
| H00004321-Q01-25 |
MMP-12 |
||||||
|
Human | Purified |
25 µg /
€500.00
|
||||
| Abnova Taiwan Corp. | |||||||
| PY-20095 |
MMP-12 (1-33, His-tagged) |
||||||
|
Human | Purified | > 90 % | E. coli |
1 mg /
€550.00
|
||
| Genesis Biotech Inc. | |||||||
Positive controls for MMP-12 (1 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| NBL1-13151 |
MMP12 Lysate |
||||||
![Western Blot: MMP12 Lysate [NBL1-13151] - Western Blot experiments.
Left-Control; Right -Over-expression Lysate for MMP12](http://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/Novus/MMP12 Lysate-Western Blot-NBL1-13151-img0001.jpg) |
0.1 mg /
€500.00
|
||||||
| Novus Biologicals Inc. | |||||||
Recommended Secondary Antibodies for MMP-12 (6 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1364AP |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | AP | |||||
| Acris Antibodies GmbH | |||||||
| R1364B |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | Biotin | |||||
| Acris Antibodies GmbH | |||||||
| R1364F |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | FITC | |||||
| Acris Antibodies GmbH | |||||||
| R1364HRP |
Rabbit IgG (H+L chain) antibody |
||||||
|
Goat | HRP | |||||
| Acris Antibodies GmbH | |||||||
| R1364T |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | TRITC | |||||
| Acris Antibodies GmbH | |||||||
| R1427R |
Rabbit IgG F(ab)2 Fragment (H+L chain) antibody |
||||||
|
|
Donkey | PE | |||||
| Acris Antibodies GmbH | |||||||
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