NB110-57217 MMP-17 antibody

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0.1 ml / €430.00
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Rabbit anti Human, Mouse, Rat MMP-17 EP1270Y

NB110-57217

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  • NB110-57217
  • NB110-57217

Product Description for MMP-17

Rabbit anti Human, Mouse, Rat MMP-17 EP1270Y.
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Paraffin Sections, Western blot / Immunoblot.

Properties for MMP-17

Product Category Antibodies
Quantity 0.1 ml
Synonyms MMP17, MT4MMP, Matrix metalloproteinase-17, Membrane-type matrix metalloproteinase 4
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications ICC/IF, P, WB
Clonality Monoclonal
Clone EP1270Y
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q9ULZ9
Genename:
4326
Antibody type Ab
Isotype control PP501P
Application Immunocytochemistry, immunohistochemistry, Western Blot, Immunohistochemistry, Western Blot and Immunocytochemistry, immunohistochemistry 1:50 -100, Western Blot 1:1000, Immunocytochemistry 1:50 -100
Background Membrane type (MT) matrix metalloproteinases (MMPs) are recently recognized members of the family of Zn(2+)- and Ca(2+)-dependent MMPs. MMP-17 is, therefore, a competent Zn(2+)-dependent MMP with unique specificity among synthetic substrates and the capability to both degrade gelatin and activate progelatinase A (1). (MMP-17) is expressed mainly in the brain, leukocytes, the colon, the ovary, and the testis. The expression of MMP-17 in leukocytes together with its putative membrane localization suggest that this enzyme could be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators such as tumor necrosis factor-alpha (2). glycosylphospha-tidylinositol (GPI) anchoring of MT4-MMP on the cell surface indicates a unique biological function and character for this proteinase (3).
General Readings
  1. Puente XS, et al. Cancer Res. 56(5):944-9, 1996.
  2. Wang Y, et al. J Biol Chem. 274(46):33043-9, 1999.
  3. Itoh Y, et al. J Biol Chem 274(48):34260-6, 1999.
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Format
Buffer System:
0.01% Sodium Azide
State:
Aff - Purified
Specificity
Specificity:
A synthetic peptide corresponding to residues on human MMP-17 was used as an immunogen.
Species:
Human, Mouse, Rat
Gene ID 4326
FocusOn and Reviews
Reviews:
Targets

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