MMP-3

Product Description for MMP-3

Rabbit anti Human, Mouse, Rat MMP-3.
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Paraffin Sections, Western blot / Immunoblot.

Properties for MMP-3

Product Category	Antibodies
Quantity	0.1 mg
Synonyms	MMP3, Matrix metalloproteinase-3, Review 001, SL-1, STMY1, Stromelysin-1, Transin-1
Presentation	Aff - Purified
Reactivity	Hu, Ms, Rt
Applications	ICC/IF, P, WB
Clonality	Polyclonal
Host	Rabbit
Isotype	IgG
Shipping to	Not USA/Canada
PDF datasheet	View Datasheet
Manufacturer	Novus Biologicals Inc.

Datasheet Extract

Immunogen	Swiss Prot Num: P08254 Genename: 4314
Antibody type	Ab
Add. information	Research Areas: Cancer
Application	ELISA, immunohistochemistry, Western Blot, Western blot analysis of Cytochrome c (H19) antibody in extracts from 293 cells. Immunohistochemistry analysis of Cytochrome c (H19) antibody in paraffin-embedded human breast carcinoma tissue., ELISA 1:10000-1:20000, Western Blot 1:500-1:1000, immunohistochemistry 1:50-1:200,
Background	Cytochrome c is a well characterized mobile electron transport protein essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial intermembrane space. More recent studies have identifed cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is translocated from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3
Concentration	1 mg/ml
Storage	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format	Purification: Immunogen affinity purified Buffer System: 15mM Sodium Azide Purity: Immunogen affinity purified State: Aff - Purified
Specificity	Specificity: Cytochrome c (H19) detects endogenous levels of Cytochrome c protein. Species: Human, Mouse, Rat
Gene ID	4314
FocusOn and Reviews	Reviews: Antibodies to Matrix Metalloproteinases - Product Review 01
Targets	MMP-3 antibody

Accessory Products

Proteins and/or Positive Controls

Proteins for MMP-3 (7 products)

Catalog No.	Species	Pres.	Purity	Source
AR09439PU-N	MMP-3
	Human		> 98 %	E. coli	10 µg / €230.00
					Acris Antibodies GmbH
AR09439PU-S	MMP-3
	Human		> 98 %	E. coli	2 µg / €130.00
					Acris Antibodies GmbH
PA1265X	MMP-3
	Human	Purified	> 98 %	E. coli	Regular Price: 20 µg / €170.00 Special Price: 20 µg / €119.00
					Acris Antibodies GmbH
H00004314-P01-10	MMP-3
	Human	Purified			10 µg / €350.00
					Abnova Taiwan Corp.
H00004314-P01-25	MMP-3
	Human	Purified			25 µg / €500.00
					Abnova Taiwan Corp.
H00004314-Q01-10	MMP-3
	Human			in vitro transl.	10 µg / €350.00
					Abnova Taiwan Corp.
H00004314-Q01-25	MMP-3
	Human			in vitro transl.	25 µg / €500.00
					Abnova Taiwan Corp.

Positive controls for MMP-3 (2 products)

Catalog No.	Species
H00004314-T01	MMP3 293T Cell Transient Overexpression Lysate(Denatured)
		0.1 ml / €240.00
		Abnova Taiwan Corp.
NBL1-13159	MMP3 Lysate
		0.1 mg / €370.00
		Novus Biologicals Inc.

Recommended Secondary Antibodies for MMP-3 (6 products)

Catalog No.	Host	Pres.
R1364AP	Rabbit IgG (H+L chain) antibody
	Goat	AP
			Acris Antibodies GmbH
R1364B	Rabbit IgG (H+L chain) antibody
	Goat	Biotin
			Acris Antibodies GmbH
R1364F	Rabbit IgG (H+L chain) antibody
	Goat	FITC
			Acris Antibodies GmbH
R1364HRP	Rabbit IgG (H+L chain) antibody
	Goat	HRP
			Acris Antibodies GmbH
R1364T	Rabbit IgG (H+L chain) antibody
	Goat	TRITC
			Acris Antibodies GmbH
R1427R	Rabbit IgG F(ab)2 Fragment (H+L chain) antibody
	Donkey	PE
			Acris Antibodies GmbH