SP7152P PUMA alpha isoform (N-term) antibody

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0.1 mg / €280.00
Please visit the appropriate website of Acris Antibodies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse PUMA

SP7152P

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  • SP7152P
  • SP7152P

Product Description for PUMA

Rabbit anti Human, Mouse PUMA.
Properties: alpha isoform (N-term)
Presentation: Purified
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for PUMA

Product Category Antibodies
Quantity 0.1 mg
Synonyms BBC3, Bcl-2-binding component 3, JFY-1, Review 004, p53 up-regulated modulator of apoptosis
Presentation Purified
Reactivity Hu, Ms
Applications C, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH

Datasheet Extract

Immunogen
Swiss Prot Num:
Q9BXH1
Immunogen:
Synthetic peptides of Human PUMA alpha (N-term)
Genename:
27113
Property alpha isoform, N-term
Antibody type Ab
Application Western blot: 0.5-1.0 µg/ml. 
Immunohistochemistry on Paraffin Sections: 10 µg/ml.
Recommended Positive Control: 3T3 cells, K562 cells.
Background A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) in human and mouse. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Concentration 1 mg/ml
General Readings
  • Nakano K., et al. Mol Cell. 7(3):683-94 (2001).
  • Yu J., et al. Mol Cell. Vol 7,673-682 (2001).
  • Han J., et al. Proc Natl Acad Sci U S A. 98(20):11318-23 (2001). 
  •  Toth A, JR Jeffers, P Nickson, J-Y Min, JP Morgan, GP Zambetti, P Erhardt. Am J Physiol Heart Circ Physiol. 291:H52-H60 (2006). 
  • Karst M A, D L Dai, M Martinka, G Li. Oncogene 24:1111-1116 (2005). 
  • Fandy E T, D D Ross, S D Gore, R K Srivastava. Cancer Chemotherapy & Pharmacology 60:313-319 (2006).
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Format
Purification:
Protein G Chromatography
Buffer System:
PBS
Preservatives:
0.02% Sodium Azide
State:
Liquid purified Ig fraction
Purified
Specificity
Specificity:
This antibody is specific for PUMA alpha (N-term).
Species:
Human, Mouse.
Gene ID 27113
FocusOn and Reviews
Reviews:
Targets

Accessory Products

Proteins and/or Positive Controls

Proteins for PUMA (2 products)

Catalog No. Species Pres. Purity   Source  
GTX29644

PUMA

PUMA
50 µg / €250.00
  GeneTex Inc.
GTX29646

PUMA

PUMA
50 µg / €230.00
  GeneTex Inc.

Positive controls for PUMA (1 products)

Catalog No. Species Pres. Purity   Source  
NBL1-07925

PUMA Lysate

Western Blot: PUMA Lysate [NBL1-07925] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for BBC3
0.1 mg / €370.00
  Novus Biologicals Inc.