Product Description for SOCS2 / CIS2
Rabbit anti Human SOCS2 / CIS2.
Properties: (C-term)
Presentation: Purified
Product is tested for Paraffin Sections.
Properties: (C-term)
Presentation: Purified
Product is tested for Paraffin Sections.
Properties for SOCS2 / CIS2
| Product Category | Antibodies |
|---|---|
| Quantity | 1 ml |
| Synonyms | CIS-2, Cytokine-inducible SH2 protein 2, FocusOn002, SOCS-2, SSI-2, SSI2, STAT-induced STAT inhibitor 2, STATI2, Suppressor of cytokine signaling 2 |
| Presentation | Purified |
| Reactivity | Hu |
| Applications | P |
| Clonality | Polyclonal |
| Host | Rabbit |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | Acris Antibodies GmbH |
Datasheet Extract
| Immunogen |
|
|---|---|
| Property | C-term |
| Antibody type | Ab |
| Application | Immunohistochemistry on Paraffin Sections: 1/100 for 30 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Positive Control: Pancreas. |
| Background | Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. |
| Storage | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch. |
| Format |
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| Species Reactivity |
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| Specificity |
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| Gene ID | 8835 |
| FocusOn and Reviews |
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| Targets |
Accessory Products
Proteins and/or Positive Controls
Proteins for SOCS2 / CIS2 (2 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| H00008835-P01-10 |
SOCS2 / CIS2 |
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 |
Human | Purified |
10 µg /
€350.00
|
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| Abnova Taiwan Corp. | |||||||
| H00008835-P01-25 |
SOCS2 / CIS2 |
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|
Human | Purified |
25 µg /
€500.00
|
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| Abnova Taiwan Corp. | |||||||
Positive controls for SOCS2 / CIS2 (1 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| NBL1-16326 |
SOCS2 Lysate |
||||||
![Western Blot: SOCS2 Lysate [NBL1-16326] - Western Blot experiments.
Left-Control; Right -Over-expression Lysate for SOCS2](http://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/Novus/SOCS2 Lysate-Western Blot-NBL1-16326-img0001.jpg) |
0.1 mg /
€370.00
|
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| Novus Biologicals Inc. | |||||||
Recommended Secondary Antibodies for SOCS2 / CIS2 (6 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1364AP |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | AP | |||||
| Acris Antibodies GmbH | |||||||
| R1364B |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | Biotin | |||||
| Acris Antibodies GmbH | |||||||
| R1364F |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | FITC | |||||
| Acris Antibodies GmbH | |||||||
| R1364HRP |
Rabbit IgG (H+L chain) antibody |
||||||
|
Goat | HRP | |||||
| Acris Antibodies GmbH | |||||||
| R1364T |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | TRITC | |||||
| Acris Antibodies GmbH | |||||||
| R1427R |
Rabbit IgG F(ab)2 Fragment (H+L chain) antibody |
||||||
|
|
Donkey | PE | |||||
| Acris Antibodies GmbH | |||||||
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