TIMP1

Product Description for TIMP1

Mouse anti Human, Monkey TIMP1 2A5.
Presentation: Purified
Product is tested for Frozen Sections, Enzyme Immunoassay, Western blot / Immunoblot.

Properties for TIMP1

Product Category	Antibodies
Quantity	0.2 mg
Synonyms	CLGI, EPA, Erythroid-potentiating activity, Fibroblast collagenase inhibitor, Metalloproteinase inhibitor 1, Review 002, TIMP, TIMP-1, Tissue inhibitor of metalloproteinases
Presentation	Purified
Reactivity	Hu, Mky
Applications	C, E, WB
Clonality	Monoclonal
Clone	2A5
Host	Mouse
Isotype	IgG1
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH

Datasheet Extract

Immunogen	Swiss Prot Num: P01033 Genename: 7076
Antibody type	Ab
Application	ELISA. Immunohistochemistry on paraffin sections: 1 - 5 µg/ml. Western Blot: 1 - 2 µg/ml.
Background	TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases-1, -2, -3 and -4) complex with metalloproteinases such as collagenases, gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 was found to be identical to EPA (erythroidpotentiation activity). Parathyroid hormone has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart and low levels of TIMP-4 are expressed in liver, brain, lung, thymus and spleen.
Concentration	Lot specific
General Readings	Hoikkala, S., et al. (2006). Tissue MMP-2 and MMP-9 [corrected] are better prognostic factors than serum MMP-2/TIMP-2-complex or TIMP-1 [corrected] in stage [corrected] I-III lung carcinoma. Cancer Lett. 236(1):125 - 132 Bodden, M.K., et al. (1994). Functional domains of human TIMP-1 (tissue inhibitor of metalloproteinases). J. Biol. Chem. 269(29):18943 - 18952
Storage	The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Format	Buffer System: Phosphate buffered saline with 0.08% sodium azide Purity: Purified State: Liquid purified Ig Purified
Specificity	Specificity: This antibody reacts to Tissue Inhibitor of Matrix Metalloproteinase 1. Species: Human, Macaca.
Gene ID	7076
FocusOn and Reviews	Reviews: Antibodies to TIMP Protein Family - Product Review 02
Targets	TIMP1 antibody

Accessory Products

Proteins and/or Positive Controls

Proteins for TIMP1 (4 products)

Catalog No.	Species	Purity	Source
AR09487PU-N	TIMP1
	Human	> 95 %	E. coli	10 µg / €230.00
				Acris Antibodies GmbH
AR09487PU-S	TIMP1
	Human	> 95 %	E. coli	2 µg / €130.00
				Acris Antibodies GmbH
H00007076-P01-10	TIMP1
	Human		in vitro transl.	10 µg / €350.00
				Abnova Taiwan Corp.
H00007076-P01-25	TIMP1
	Human		in vitro transl.	25 µg / €500.00
				Abnova Taiwan Corp.

Positive controls for TIMP1 (1 products)

Catalog No.	Species
NBL1-16924	TIMP1 Lysate
		0.1 mg / €370.00
		Novus Biologicals Inc.

Recommended Secondary Antibodies for TIMP1 (8 products)

Catalog No.	Host	Pres.
R1253AP	Mouse IgG (H+L chain) antibody
	Rabbit	AP
			Acris Antibodies GmbH
R1253B	Mouse IgG (H+L chain) antibody
	Rabbit	Biotin
			Acris Antibodies GmbH
R1253F	Mouse IgG (H+L chain) antibody
	Rabbit	FITC
			Acris Antibodies GmbH
R1253HRP	Mouse IgG (H+L chain) antibody
	Rabbit	HRP
			Acris Antibodies GmbH
R1253TR	Mouse IgG (H+L chain) antibody
	Rabbit	Texas Red
			Acris Antibodies GmbH
R1403R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Rabbit	PE
			Acris Antibodies GmbH
R1405R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Goat	PE
			Acris Antibodies GmbH
R1455R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Donkey	PE
			Acris Antibodies GmbH