TIMP1

Product Description for TIMP1

Mouse anti Human TIMP1 MM0034-4A16.
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for TIMP1

Product Category	Antibodies
Quantity	0.1 mg
Synonyms	CLGI, EPA, Erythroid-potentiating activity, Fibroblast collagenase inhibitor, Metalloproteinase inhibitor 1, Review 002, TIMP, TIMP-1, Tissue inhibitor of metalloproteinases
Presentation	Purified
Reactivity	Hu
Applications	P, WB
Clonality	Monoclonal
Clone	MM0034-4A16
Host	Mouse
Isotype	IgG1
Shipping to	Not USA/Canada
PDF datasheet	View Datasheet
Manufacturer	Novus Biologicals Inc.

Datasheet Extract

Immunogen	Swiss Prot Num: P01033 Immunogen: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with purified recombinant human tissue inhibitor of metalloproteinases-1 (TIMP-1). Genename: 7076
Antibody type	Ab
Add. information	Research Areas: Cancer
Application	immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot, Western Blot, Immunohistochemistry Paraffin and Frozen, immunohistochemistry 1:25 - 1:50, Western Blot 1:100-1:1000, Immunohistochemistry-Paraffin 1:25 - 1:50, Immunohistochemistry-Frozen 1:25 - 1:50
Background	Tissue inhibitor of metalloproteinases 1 (TIMP1) and Tissue inhibitor of metalloproteinases 2 (TIMP 2) have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP1 forms a complex of 1:1 stoichiometry with activated interstitial collagenases, activated stromelysin, active form of 72kDa Type IV collagenase (also known as MMP2 or gelatinase A), and latent and active forms 92kDa Type IV collagenase (also known as MMP0 or gelatinase B). TIMPs inhibit the proteolytic invasiveness of tumour cells and normal placental trophoblast cells. TIMP1 is produced in low (pg/ml) levels by most cell types. Treatment of cells with the phorbol ester TPA stimulates production of TIMP1 in some cell types, but the low protein levels produced often require concentration of cell culture media to visualize the bands by Western Blotting.
Storage	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format	Purification: protein G purified Buffer System: No Preservative Purity: protein G purified State: Purified
Specificity	Specificity: TIMP1 (MM0034-4A16) Species: Human
Gene ID	7076
FocusOn and Reviews	Reviews: Antibodies to TIMP Protein Family - Product Review 02
Targets	TIMP1 antibody

Accessory Products

Proteins and/or Positive Controls

Proteins for TIMP1 (4 products)

Catalog No.	Species	Purity	Source
AR09487PU-N	TIMP1
	Human	> 95 %	E. coli	10 µg / €230.00
				Acris Antibodies GmbH
AR09487PU-S	TIMP1
	Human	> 95 %	E. coli	2 µg / €130.00
				Acris Antibodies GmbH
H00007076-P01-10	TIMP1
	Human		in vitro transl.	10 µg / €350.00
				Abnova Taiwan Corp.
H00007076-P01-25	TIMP1
	Human		in vitro transl.	25 µg / €500.00
				Abnova Taiwan Corp.

Positive controls for TIMP1 (1 products)

Catalog No.	Species
NBL1-16924	TIMP1 Lysate
		0.1 mg / €370.00
		Novus Biologicals Inc.

Recommended Secondary Antibodies for TIMP1 (8 products)

Catalog No.	Host	Pres.
R1253AP	Mouse IgG (H+L chain) antibody
	Rabbit	AP
			Acris Antibodies GmbH
R1253B	Mouse IgG (H+L chain) antibody
	Rabbit	Biotin
			Acris Antibodies GmbH
R1253F	Mouse IgG (H+L chain) antibody
	Rabbit	FITC
			Acris Antibodies GmbH
R1253HRP	Mouse IgG (H+L chain) antibody
	Rabbit	HRP
			Acris Antibodies GmbH
R1253TR	Mouse IgG (H+L chain) antibody
	Rabbit	Texas Red
			Acris Antibodies GmbH
R1403R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Rabbit	PE
			Acris Antibodies GmbH
R1405R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Goat	PE
			Acris Antibodies GmbH
R1455R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Donkey	PE
			Acris Antibodies GmbH