TIMP2

Product Description for TIMP2

Mouse anti Chicken, Human, Mouse, Porcine, Rabbit, Zebrafish TIMP2 3A4.
Presentation: Purified
Product is tested for Frozen Sections, Enzyme Immunoassay, Western blot / Immunoblot.

Properties for TIMP2

Product Category	Antibodies
Quantity	0.2 mg
Synonyms	CSC-21K, Metalloproteinase inhibitor 2, TIMP-2, Tissue inhibitor of metalloproteinases 2
Presentation	Purified
Reactivity	Chk, Hu, Ms, Por, Rb, Ze
Applications	C, E, WB
Clonality	Monoclonal
Clone	3A4
Host	Mouse
Isotype	IgG2a
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH

Datasheet Extract

Immunogen	Swiss Prot Num: P16035 Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the human TIMP-2 protein and mouse myeloma Ag8563 cells. Sequence common in mouse, rabbit, chicken, zebrafish and pig. Genename: 7077
Antibody type	Ab
Application	ELISA. Western Blot: 1 - 2 µg/ml. Immunohistochemistry on paraffin sections: 1 - 5 µg/ml. Positive Control: Colon and gastric tissues. Stronger expressions observed in tumor versus normal proteins.
Background	TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases-1, -2, -3 and -4) complex with metalloproteinases such as collagenases,gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 was found to be identical to EPA (erythroidpotentiation activity). Parathyroid hormone has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation,branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart and low levels of TIMP-4 are expressed in liver, brain, lung, thymus and spleen.
Concentration	0,95 mg/ml
General Readings	Hoikkala, S., et al. (2006). Tissue MMP-2 and MMP-9 [corrected] are better prognostic factors than serum MMP-2/TIMP-2-complex or TIMP-1 [corrected] in stage [corrected] I-III lung carcinoma. Cancer Lett. 236(1):125 - 132 Ring P, Johansson K, Höyhtyä M, Rubin K, Lindmark G. Expression of tissue inhibitor of metalloproteinases TIMP-2 in human colorectal cancer--a predictor of tumour stage. Br J Cancer. 1997;76(6):805-11. PubMed PMID: 9310250.
Storage	The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Format	Buffer System: Phosphate buffered saline containing 0.08% sodium azide as preservative Purity: Purified State: Liquid purified Ig fraction Purified
Specificity	Specificity: This antibody reacts to Matrix Metalloproteinase 2 (TIMP2). Species: Human, Mouse, Rabbit, Chicken, Zebrafish, Pig.
Gene ID	7077
FocusOn and Reviews	Reviews: Antibodies to TIMP Protein Family - Product Review 02
Targets	TIMP2 antibody

Accessory Products

Proteins and/or Positive Controls

Proteins for TIMP2 (2 products)

Catalog No.	Species	Source
H00007077-P01-10	TIMP2
	Human	in vitro transl.	10 µg / €350.00
			Abnova Taiwan Corp.
H00007077-P01-25	TIMP2
	Human	in vitro transl.	25 µg / €500.00
			Abnova Taiwan Corp.

Positive controls for TIMP2 (2 products)

Catalog No.	Species
H00007077-T01	TIMP2 293T Cell Transient Overexpression Lysate(Denatured)
		0.1 ml / €240.00
		Abnova Taiwan Corp.
NBL1-16925	TIMP2 Lysate
		0.1 mg / €370.00
		Novus Biologicals Inc.

Recommended Secondary Antibodies for TIMP2 (8 products)

Catalog No.	Host	Pres.
R1253AP	Mouse IgG (H+L chain) antibody
	Rabbit	AP
			Acris Antibodies GmbH
R1253B	Mouse IgG (H+L chain) antibody
	Rabbit	Biotin
			Acris Antibodies GmbH
R1253F	Mouse IgG (H+L chain) antibody
	Rabbit	FITC
			Acris Antibodies GmbH
R1253HRP	Mouse IgG (H+L chain) antibody
	Rabbit	HRP
			Acris Antibodies GmbH
R1253TR	Mouse IgG (H+L chain) antibody
	Rabbit	Texas Red
			Acris Antibodies GmbH
R1403R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Rabbit	PE
			Acris Antibodies GmbH
R1405R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Goat	PE
			Acris Antibodies GmbH
R1455R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Donkey	PE
			Acris Antibodies GmbH