TLR11 - AP09157PU-N | acris-antibodies.com

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Product Description for TLR11

Rabbit anti Human, Mouse TLR11.
Presentation: Ig Fraction
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for TLR11

Product Category	Antibodies
Quantity	0.1 mg
Synonyms	FocusOn004, Gm287, Toll-like receptor 11
Presentation	Ig Fraction
Reactivity	Hu, Ms
Applications	E, WB
Clonality	Polyclonal
Host	Rabbit
Isotype	IgG
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH

Datasheet Extract

Immunogen	Swiss Prot Num: Q6R5P0 Immunogen: Synthetic peptide corresponding to a region near the carboxy terminus of mouse toll-like receptor 11 (TLR11) protein Genename: 239081
Antibody type	Ab
Application	ELISA: 1/10,000 - 1/40,000. Western Blot: 0.5 - 2 µg/ml.
Background	Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR11 is one of three mouse TLRs that lack a human ortholog. It is activated specifically by uropathogenic bacteria, and mice lacking TLR11 showed a much greater susceptability to uropathogenic infections, indicating a potentially important role for TLR11 in preventing infections in the urogenital system.
Concentration	1.0 mg/ml (by UV absorbance at 280 nm)
General Readings	Vogel SN, Fitzgerald KA, Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol Interv. 2003 Dec;3(8):466-77. PubMed PMID: 14993454. Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76. Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216. O'Neill LA, Fitzgerald KA, Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends Immunol. 2003 Jun;24(6):286-90. PubMed PMID: 12810098. McGettrick AF, O'Neill LA. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol Immunol. 2004 Jul;41(6-7):577-82. PubMed PMID: 15219996. Tabeta K, Georgel P, Janssen E, Du X, Hoebe K, Crozat K, et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3516-21. Epub 2004 Mar 1. PubMed PMID: 14993594. Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA, et al. A toll-like receptor that prevents infection by uropathogenic bacteria. Science. 2004 Mar 5;303(5663):1522-6. PubMed PMID: 15001781.
Storage	Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Format	Purification: Ion exchange chromatography Buffer System: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.02% (w/v) Sodium Azide State: Liquid IgG fraction Ig Fraction
Specificity	Specificity: This antibody is directed against TLR11 protein. Species: Human.
Gene ID	239081
FocusOn and Reviews	FocusOns: Antibodies to Toll-Like Receptor (TLR) Family - FocusOn 004
Targets	TLR11 antibody

Accessory Products

Recommended Secondary Antibodies for TLR11 (6 products)

Catalog No.	Host	Clone/Iso.	Pres.		React.	Applications
R1364AP	Rabbit IgG (H+L chain) antibody
	Goat		AP
							Acris Antibodies GmbH
R1364B	Rabbit IgG (H+L chain) antibody
	Goat		Biotin
							Acris Antibodies GmbH
R1364F	Rabbit IgG (H+L chain) antibody
	Goat		FITC
							Acris Antibodies GmbH
R1364HRP	Rabbit IgG (H+L chain) antibody
	Goat		HRP
							Acris Antibodies GmbH
R1364T	Rabbit IgG (H+L chain) antibody
	Goat		TRITC
							Acris Antibodies GmbH
R1427R	Rabbit IgG F(ab)2 Fragment (H+L chain) antibody
	Donkey		PE
							Acris Antibodies GmbH

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