SP7359P TLR11 antibody

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0.1 mg / €320.00
Delivery Time: 5-7 working days

Quick Overview

Rabbit anti Mouse TLR11

Product Description for TLR11

Rabbit anti Mouse TLR11.
Presentation: Purified
Product is tested for Western blot / Immunoblot, Flow Cytometry.

Properties for TLR11

Product Category Antibodies
Quantity 0.1 mg
Synonyms FocusOn004, Gm287, Toll-like receptor 11
Presentation Purified
Reactivity Ms
Applications F, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH

Datasheet Extract

Immunogen
Swiss Prot Num:
Q6R5P0
Immunogen:
A synthetic peptide within amino acid residues 911-926 of mouse TLR11
AA Sequence:
CEQLKRRLSKAGQERD
Genename:
239081
Remarks:
Genbank accession no. NP_991388
Antibody type Ab
Application Flow Cytometry (2-5 µg / 10e6 cells).
Western blot (1-3 µg/ml).
Recommended Positive Control: mouse kidney tissue lysate.
Background The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLR11 does not respond to known TLR ligands but instead respond specifically to uropathogenic bacteria. TLR11-deficient mice are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating that TLR11 may play a protective role in preventing infection of internal organs of the urogenital system.
Concentration 0.5 mg/ml
General Readings
  • Muzio M, Natoli G, Saccani S, Levrero M, and Mantovani A. J. Exp. Med. 187: 2097-2101 (1998).
  • Medzhitov R and Janeway CA. Cell 91: 295-298 (1997).
  • Tabeta,K., Georgel,P., Janssen,E., Du,X., Hoebe,K., Crozat,K.,Mudd,S., Shamel,L.,Sovath,S., Goode,J., Alexopoulou,L.,Flavell,R.A. and Beutler,B. Proc. Natl. Acad. Sci. U.S.A. 101 (10), 3516-3521 (2004).
Storage Store the antibody at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein G chromatography
Buffer System:
PBS containing 0.2% Gelatin and 0.05% Sodium Azide as preservative.
State:
Liquid Ig fraction
Purified
Specificity
Specificity:
This antibody is specific for TLR11.
Species:
Mouse and Rat.
Gene ID 239081
FocusOn and Reviews
FocusOns:
Targets

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