You have no items in your shopping cart.
Product Description for Caspase-1
Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme
Properties for Caspase-1
| Manufacturer | Acris Antibodies GmbH |
| Quantity | 50 µg |
| Presentation | Purified |
| Shipping to | Worldwide |
Datasheet Extract
| Synonyms | CASP-1, CASP1, IL1BC, IL1BCE, ICE, p45, FocusOn051 |
| Swiss Prot Num | P29466 |
| Product Type | Antibodies |
| Storage | Store the antibody undiluted at -20°C or for long term storage (in aliquots) at -70°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Format | State: Liquid |
| Buffer System: PBS, pH 7.2, containing 0.1% BSA and 0.02% thimerosal | |
| Specificity | The peptide is used for blocking the antibody activity of active Caspase-1 (AP00006PU-N). |
| Application | Western Blot: It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37°C. |
| Background | Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase 1 is similar to the cell death gene CED3 of C. elegans and regulates multiple proinflammatory cytokines, including Interleukin 1b and interferon-gamma-inducing factor. Caspase 1 plays a role down stream of Caspase 8 which is involved in Fas-mediated apoptosis. |
| Concentration | 0.2 mg/ml |
| Focuson | 051 Antibodies to Caspase Family |
