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Product Description for Cathepsin D
Properties for Cathepsin D
| Manufacturer | Acris Antibodies GmbH |
| Quantity | 0.1 mg |
| Reactivity | Human |
| Presentation | Purified |
| Applications | Paraffin Sections, Western blot / Immunoblot |
| Host | Rabbit |
| PDF datasheet | view  |
| Shipping to | Worldwide |
Datasheet Extract
| Synonyms | CTSD, CPSD, Review 026 |
| Swiss Prot Num | P07339 |
| Immunogen | Human cathepsins D |
| Product Type | Antibodies |
| Storage | Store the antibody at -4°C for one month or (in aliquots) at -20°C to -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Format | State: Liquid purified Ig fraction. |
| Purification: Affinity Chromatography. | |
| Buffer System: PBS, pH 7.2 containing 30% Glycerol, 0.5% BSA as stabilizer and 0.01% Thimerosal as preservative. | |
| Specificity | The antibody detects both the 52 kDa proform and the 34 kDa (but not the 14 kDa) subunit of Cathepsin D. |
| Application | Western Blot: 2-4 µg/ml. Immunohistochemistry on Paraffin Sections: 10-20 µg/ml. |
| Background | Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer. |
| Concentration | 0.2 mg/ml |
| Species Reactivity | Tested: Human. |
| Review | r026 Antibody Panel to Cathepsin Protease Family |
Secondary Antibodies for Cathepsin D
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / 190 Euro | |||||
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / 160 Euro | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / 160 Euro | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / 170 Euro | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / 160 Euro | |||||
| R1427R | Rabbit IgG F(ab)2 Fragment | ||||||
| Donkey | PE | 1 ml / 290 Euro | |||||
| R1458C2 | Rabbit IgG (H&L) | ||||||
| Goat | Cy2 | 1 mg / 250 Euro | |||||
| R1458C3 | Rabbit IgG (H&L) | ||||||
| Goat | Cy3 | 1 mg / 250 Euro | |||||
| R1458C5 | Rabbit IgG (H&L) | ||||||
| Goat | Cy5 | 1 mg / 250 Euro | |||||
