Glutamate receptor 1 pSer845 AP05908PU-N

AMPA-selective glutamate receptor 1

Synonyms	GluR-1, GRIA1, GLUH1, GLUR1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, FocusOn108
Swiss Prot Num	P42261
Immunogen	Synthetic phosphopeptide corresponding to an amino acid sequence within rat GluR1 which includes phosphorylated Ser845.
Product Type	Antibodies
Storage	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
References	1. Castellani, G.C. et al. (2001) A biophysical model of bidirectional synaptic plasticity: Dependence on AMPA and NMDA receptors. Proc. Natl. Acad. Sci. USA. 98: 12772 - 12777.
Format	State: Liquid purified Ig fraction.
	Purification: Affinity Chromatography
	Buffer System: 10mM HEPES, pH7.5 containing 0.09% Sodium Azide, 0.01% BSA and 50% Glycerol.
Specificity	This antibody is specific for glutamate receptor subunit 1 (GluR1) when phosphorylated at serine 845.
Application	Western Blot (1/1000): Detects a band of approximately 100kDa in rat brain lysates.
Background	GluR1, widely expressed throughout the nervous system, is a component of AMPA receptors (alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid receptors), which play a key role at excitatory synapses. Phosphorylation of Ser831 and Ser845 is reported to potentiate GluR1 function, suggesting a possible role in synaptic plasticity, learning and memory.
Focuson	108 Metabotropic Glutamate Receptor Antibodies