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Product Description for CGRP / CALCA
Properties for CGRP / CALCA
| Manufacturer | Acris Antibodies GmbH |
| Quantity | 0.1 ml |
| Reactivity | Mouse, Rat, Reptiles |
| Presentation | Ig Fraction |
| Applications | Frozen sections, Enzyme Immunoassay, Paraffin Sections |
| Host | Goat |
| PDF datasheet | view  |
| Shipping to | Worldwide |
Datasheet Extract
| Synonyms | Calcitonin gene-related peptide I, Alpha-type CGRP, CALC1, CGRP-I |
| Swiss Prot Num | P01256 |
| Immunogen | Synthetic rat Tyr-CGRP (23-37) conjugated to gamma globulin |
| Product Type | Antibodies |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Collins, J.J. et al (2000) Distribution and origin of secretoneurin-immunoreactive nerves in the female rat uterus Neuroscience 95: 255-264. 2. Pritz. M.B. and Stritzel, M.E. (1988) Thalamic nuclei that project to reptilian telencephalon lack GABA and GAD immunoreactive neurons and puncta Brain Res. 457: 154-159. 3. Pritz. M.B. and Stritzel, M.E. (1989) Reptilian dorsal column nucleus lacks GAD immunoreactive neurons. Brain Res. 503: 175-179. |
| Format | State: Liquid purified IgG fraction |
| Purification: Protein G affinity chromatography | |
| Buffer System: PBS containing 0.09% sodium azide as preservative | |
| Specificity | Antibody is reactive with whole molecule (1-37) and 23-37 fragment (C- term). Specifically visualises CGRP in brain cells. |
| Add. information | The antibody has been described to work with reptilian material. |
| Application | ELISA (1/500-1/2500). Immunohistochemistry. |
| Background | CGRP is present in C-cells of the thyroid and in central and peripheral nerves. CGRP has several important physiologic roles: it is a potent vasodilator, and can affect the force and rate of heart beat; it can modulate acetylcholine receptor function at the neuromuscular junction; it has been demonstrated to block tolerance to morphine; and it can modulate antigen presentation in Langerhans cells in the skin. Despite these important physiologic functions, therapeutic strategies using CGRP have been impeded due to the lack of a cloned CGRP receptor with which ligands could be developed. |
| Concentration | 5.0 mg/ml |
Secondary Antibodies for CGRP / CALCA
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1317AP | Goat IgG (H&L) | ||||||
| Rabbit | AP | 1 mg / 180 Euro | |||||
| R1317B | Goat IgG (H&L) | ||||||
| Rabbit | Biotin | 2 mg / 170 Euro | |||||
| R1317F | Goat IgG (H&L) | ||||||
| Rabbit | FITC | 2 mg / 160 Euro | |||||
| R1317HRP | Goat IgG (H&L) | ||||||
| Rabbit | HRP | 2 mg / 170 Euro | |||||
| R1317T | Goat IgG (H&L) | ||||||
| Rabbit | TRITC | 2 mg / 160 Euro | |||||
| R1416R | Goat IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / 290 Euro | |||||
| R1435C2 | Goat IgG (H&L) multi-species ads. | ||||||
| Donkey | Cy2 | 1 mg / 250 Euro | |||||
| R1435C3 | Goat IgG (H&L) | ||||||
| Donkey | Cy3 | 1 mg / 250 Euro | |||||
| R1435C5 | Goat IgG (H&L) multi-species ads. | ||||||
| Donkey | Cy5 | 1 mg / 250 Euro | |||||
