Antibody Panel to Cannabinoid Receptors

Introduction

Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2.

Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P/Q type calcium channels.

CB1 receptors are found primarily in the brain, specifically in the basal ganglia and in the limbic system, including the hippocampus. They are also found in the cerebellum and in both male and female reproductive systems. CB1 receptors are essentially absent in the medulla oblongata, the part of the brain that is responsible for respiratory and cardiovascular functions. Thus, there is not a risk of respiratory or cardiovascular failure as there is with many other drugs. CB1 receptors appear to be responsible for the euphoric and anticonvulsive effects of cannabis.

CB2 receptors are almost exclusively found in the immune system, with the greatest density in the spleen. CB2 receptors appear to be responsible for the anti-inflammatory and possible other therapeutic effects of cannabis.

The protein sequences of these two receptors are about 45% similar. In addition, minor variations in each receptor have been identified.

Antibody Tools for the Detection of Cannabinoid Receptors

Acris Antibodies offers a range of antibodies for the detection of Cannabinoid receptors CB1 and CB2 in various applications.

Fig.1 shows staining of CB1 in Brain (Neurons) using antibody Cat.No. SP4084

Fig.2 shows immunolocalization of CB1 in rat hippocampus using antibody Cat.No. SP5262

Fig.3 shows immunolocalization of rat CB1 transfected into AtT20 cells using antibody Cat.No. SP5260

Available Antibody Panel to Cannabinoid Receptors

Cannabinoid receptor 1 (CB1, CANN6, CNR1, CNR) antibody, Cannabinoid receptor 2 (CB2, CX5, CNR2) antibody

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