Antibodies to Calcium Sensing Receptor (CaSR)

Introduction

The extracellular calcium (Ca(2+)(o))-sensing receptor (CaSR) enables the parathyroid glands and other CaSR-expressing cells involved in calcium homeostasis, such as the kidney and bone, to sense alterations in the level of Ca(2+)(o) and to respond with changes in function that are directed at normalizing the blood calcium concentration. Several disorders of Ca(2+)(o) sensing arise from inherited or acquired abnormalities that 'reset' the serum calcium concentration upwards or downwards.

Ca2+ acts as a first messenger via CaSR mediated activation of second messenger systems altering cellular physiology. Changes in extracellular calcium are thought to modulate a balance between pro¬lifera¬tion and differentiation in a variety of cell types. It has been demonstrated that malignant trans¬formations of cells are accompanied by a loss of responsiveness to the anti-proliferative effects of eleva¬ted extra¬cellular calcium. Mutations in the human CaSR gene have been identified in several inherited dis¬orders of Ca metabolism such as familial hypocalciuric hypercalcemia (FHH), neonatal severe hyper¬¬¬parathyroidism (NSHPT), and autosomal dominant hypocalcemia (ADH).

Antibody Panel to Calcium sensing Receptor (CaSR)

Acris Antibodies offers a panel of monoclonal and polyclonal antibodies for the detection of calcium sensing receptor in human, rat or mouse tissues. The antibodies can be used for Immunohistochemical methods, Paraffin sections, Immunocytochemistry as well as Western Blot.

Fig.1: Immunohistochemical staining of CaSR on human parathyroid section using antibody SP4561P.

Fig.2: Immuno-fluorescence of Bovine CE (Corneal Endothelium) Limbus tissue extracts using SM5134P.

Antibody Panel to Calcium sensing Receptor (CaSR)

Calcium sensing Receptor, CaSR antibody.

Literature

Egbuna OI, Brown EM. Hypercalcaemic and hypocalcaemic conditions due to calcium-sensing receptor mutations. Best Pract Res Clin Rheumatol. 2008 Mar;22(1):129-148.

Gunn IR, Gaffney D. Clinical and laboratory features of calcium sensing receptor disorders: a systematic review. Ann Clin Biochem. 2004 Nov; 41 (Pt6): 441-48. Review.

Msaouel P, Nixon AM, Bramos AP, Baiba E, Kentarchos NE. Extracellular calcium sensing receptor: an overview of physiology, pathophysiology and clinical perspectives. InVivo. 2004 Nov-Dec; 18(6): 739-53. Review.

Peters U, Chatterjee N, Yeager M, Chanock SJ, Schoen RE, McGlynn KA, Church TR, Weissfeld JL, Schatzkin A, Hayes RB. Association of genetic variants in the calcium sensing receptor with risk of colorectal adenoma. Cancer Epidemiol Biomarkers Prev. 2004 Dec; 13(12): 2181-6.

Busque SM, Kerstetter JE, Geibel JP, Insogna K. L-type amino acids stimulate gastric secretion by activation of the calcium sensing receptor In parietal cells. Am J Physiol Gastrointest Liver Physiol. 2005 Jun 16.

Weston AH, Absi M, Ward DT, Ohanion J, Dodd RH, Dauban P, Petrel C, Ruat M, Edwards G. Evidence in favour of a calcium sensing receptor in arterial endothelial cells . Studies with Calindol and Calhexin 231. Circ. Res. 2005 Jul 21.