Antibodies to Cadherin EGF LAG seven pass G type Receptor (CELSR1,2 and3)

Introduction

The cadherins are a major class of membrane proteins with prominent roles in cell adhesion, and the regulation of tissue organisation and morphogenesis.

Proper maintenance of cell-cell contact, communication of signals into the cellular interior and interactions with cytoskeletal elements produce changes in cell motility, migration, proliferation and shape. Cadherin mo¬lecules that are concentrated at cell-cell junctions bring about these fundamental operations. They are syn¬thesized as polypeptides and post-transcriptionally modified into proteins. Celsr, also called Flamingo (Fmi) genes encode proteins of the cadherin superfamily. Celsr cadherins are seven-pass transmembrane proteins with nine cadherin repeats in the extracellular domain, and an anonymous intracellular C-terminus. The Drosophila Fmi gene regulates epithelial planar cell polarity and dendritic field deployment.

The three Flamingo gene orthologs in man and rodents are named, respectively, CELSR1-3 and Celsr1-3. It has been reported that Celsr1 and Celsr2 expression is observed during gastrulation and within the developing nervous system. Celsr3 transcripts, however, are found only at sites of active neurogenesis.

Antibody Panel to CELSR1, 2 and 3

Acris Antibodies offers a range of polyclonal antibodies to the CELSR Family. All antibodies have been raised against different epitopes of the three CELSR molecules and can be used for Immuno¬histo¬chemistry with formalin fixed paraffin embedded tissues

Fig. 1: Immunohistochemical staining of human brain using anti-CELSR1 antibody SP4718P.

Fig. 2: Immunohistochemical staining of human lobular epithelium (breast) using anti-CELSR2 antibody SP4093P.

Fig. 3: Immunohistochemical staining of human brain (Purkinje neurons) using anti-CELSR3 antibody SP4647P.

Fig. 4: Immunohistochemical staining of human brain (Purkinje neurons) using anti-CELSR3 antibody SP4721P.

Antibody Panel to CELSR Family

Cadherin EGF LAG seven pass G, Flamingo (Fmi), CELSR1-3, antibody.

Literature

Pettitt J. The cadherin superfamily. WormBook. 2005 Dec 29; 1-9.

Beall SA, Boekelheide K, Johnson KJ. Hybrid GPCR/Cadherin (Celsr) Proteins in Rat Testis Are Expressed With Cell Type Specificity and Exhibit Differential Sertoli Cell–Germ Cell Adhesion Activity J Androl. 2005 Jul-Aug;26(4):529-38.

Tissir F, De-Backer O, Goffinet AM, Lambert de Rouvroit C. Developmental expression profiles of Celsr (Flamingo) genes in the mouse. Mech Dev. 2002 Mar;112(1-2):157-60.

Formstone CJ, Little PF The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit terns of expression during embryonic development. Mech Dev 2001 Nov;109(1):91-4.

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