Endothelial Differentiation Gene Receptors
(EDG-1,-2,-4,-5,-6,-7 and -8)

Introduction

Lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P) and some other structurally related lysophospholipids are active growth factors and stimuli for diverse cellular functions.

LPA and S1P promote early T cell migration to tissue sites of immune responses and regulate T cell proliferation and secretion of numerous cytokines. The endothelial differentiation gene (EDG) receptors are a class of G protein-coupled receptors. EDG-1, -3, -5, -6, and -8 (known as the endothelial differentiaton gene-1 family) regulate diverse processes including cell migration, angiogenesis, vascular maturation, heart development, neurite retraction and soma rounding. These receptors bind the bioactive lipid sphingosine-1-phosphate (S1P) as the primary signaling ligand. EDG-2, -4, and -7 bind the ligand lysophosphatidic acid.

Antibody Panel to EDG Receptors

Acris Antibodies offers a wide range of polyclonal antibodies to EDG-receptors suitable for Immunohistochemistry (on Paraffin-embedded tissues) and Western blotting.

Fig.1: Immunohistochemical staining of heart vessel using antibody Cat.No. SP4617P (anti-EDG-1)

Fig.2: Immunohistochemical staining of brain neurons and glia using antibody SP4371P (anti-EDG-2)

Fig.3: Immunohistochemical staining of breast carcinoma using antibody Cat.No. SP4498P (anti-EDG-5)

Fig.4:Immunohistochemical staining of lymph node using antibody Cat.No. SP4500 (anti-EDG-6)

Fig.5: Immunohistochemical staining of amygdala using antibody Cat.No. SP4375P (anti-EDG-7)

Fig.6: Immunohistochemical staining of neurons and glia in rat brain using antibody Cat.No SP4501 (anti-EDG-8)

Antibody Panel to

Endothelial Differentiation Gene Receptors (EDG-1,-2,-4,-5,-6,-7 and -8) antibody.

Literature

Kohno T, Igarashi Y. Roles for N-glycosylation in the dynamics of EDG-1/S1P1 in sphingosine 1-phosphate stimulated cells. Glycoconj J. 2004; 21(8-9): 497-501.

Laychock SG, Tian Y, Sessanna SM. Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells. Diabetes. 2003 Aug; 52(8): 1986-93.

Huang MC, Graeler M, Shankar G, Spencer J, Goetzl EJ. Lysophospholipid mediators of immunity and neoplasia. Biochim Biophys Acta. 2002 May 23; 1582(1-3): 161-7.

Toman RE, Milstien S, Spiegel S. Sphingosine-1-phosphate: an emerging therapeutic target. Expert Opin Ther Targets. 2001 Feb; 5(1): 109-23.

 

27 related products - click here to filter product result list

Antibodies

Catalog No.	Clone/Isotype		Presentation	Reactivity	Applications
ARP38402_T100	BUD31 (BUD31 homolog (S. cerevisiae))
			Purified	Hu	WB	0.1 mg / 240 €
	Rabbit	IgG	AVIVA Systems Biology
SP4662P	EDG-8 (extracell. Dom.)
	-		Aff - Purified	Hu	P	50 µg / 330 €
	Rabbit		Acris Antibodies GmbH
PC085	EDG1 (C-term)
	-		Purified	Hu	WB	0.1 mg / 560 €
	Rabbit		Kamiya Biomedical Company
SP4371P	EDG2
	-		Aff - Purified	Hu, Ms, Rt	P	50 µg / 380 €
	Rabbit		Acris Antibodies GmbH
SP4372P	EDG2
	-		Aff - Purified	Hu, Ms, Rt	P	50 µg / 380 €
	Rabbit		Acris Antibodies GmbH
SP5160P	EDG2
	-		Aff - Purified	Rt, Ms, Hu	WB	0.1 mg / 330 €
	Rabbit		Acris Antibodies GmbH
EB07416	EDG2
	-		Aff - Purified	Can, Hu, Ms, Rt		0.1 mg / 200 €
	Goat		Everest Biotech Ltd.
NB600-1096	EDG2
			Ig Fraction	Hu, Rt	WB	25 µg / 410 €
	Rabbit		Novus Biologicals Inc.
11798-1-AP	EDG2
			Aff - Purified	Hu	E, P, WB	150 µl / 320 €
	Rabbit	IgG	ProteinTech Group, Inc.
PC086	EDG2 (C-term)
	-		Purified	Hu, Rt	WB	0.1 mg / 560 €
	Rabbit		Kamiya Biomedical Company
SP5160CP	EDG2 (Control Peptide)
	-		Purified			50 µg / 130 €
			Acris Antibodies GmbH
MC913	EDG3
	cocktail		Purified	Hu, Rt	WB	0.1 mg / 670 €
	Mouse	cocktail	Kamiya Biomedical Company
SP4373P	EDG4
	-		Aff - Purified	Hu, Ms	P	50 µg / 380 €
	Rabbit		Acris Antibodies GmbH
SP4374P	EDG4
	-		Aff - Purified	Hu	P	50 µg / 380 €
	Rabbit		Acris Antibodies GmbH
SP4497P	EDG5
	-		Aff - Purified	Hu, Ms, Rt	IF, P	50 µg / 380 €
	Rabbit		Acris Antibodies GmbH
SP4734P	EDG5
	-		Aff - Purified	Hu	P	50 µg / 330 €
	Rabbit		Acris Antibodies GmbH
MC917	EDG5
	cocktail		Purified	Hu, Rt	WB	0.1 mg / 670 €
	Mouse	cocktail	Kamiya Biomedical Company
PC087	EDG6 (C-term)
	-		Purified	Hu	WB	0.1 mg / 560 €
	Rabbit		Kamiya Biomedical Company
SP4500P	EDG6 (C-term.)
	-		Aff - Purified	Hu, Ms	P	50 µg / 380 €
	Rabbit		Acris Antibodies GmbH
SP4499P	EDG6 (cytoplasm. Dom.)
	-		Aff - Purified	Hu	P	50 µg / 330 €
	Rabbit		Acris Antibodies GmbH
SP4375P	EDG7
	-		Aff - Purified	Hu	P	50 µg / 330 €
	Rabbit		Acris Antibodies GmbH
SP4376P	EDG7
	-		Aff - Purified	Hu, Ms, Rt	P	50 µg / 380 €
	Rabbit		Acris Antibodies GmbH
PC088	EDG7 (C-term)
	-		Purified	Hu	WB	0.1 mg / 560 €
	Rabbit		Kamiya Biomedical Company
SP4501P	EDG8 (extracell. Dom.)
	-		Aff - Purified	Hu	P	50 µg / 380 €
	Rabbit		Acris Antibodies GmbH
PC089	EDG8 (C-term)
	-		Purified	Hu	WB	0.1 mg / 560 €
	Rabbit		Kamiya Biomedical Company

Protein

Catalog No.	Species	Presentation	Purity		Source
10-288-22168F	HEXIM1 protein
	Human	Purified	85%		E. coli		0.1 mg / 350 Euro
							GenWay Biotech Inc.
10-288-22168F-50	HEXIM1 protein
	Human	Purified	85%		E. coli		50 µg / 250 Euro
							GenWay Biotech Inc.