Antibodies to Apelin Receptor (APJ)

Introduction

The Apelin Receptor (APJ receptor) has been identified as the endogenous receptor for the peptide Apelin.

This peptide is produced through processing from the C-terminal portion in the pre-proprotein consisting of 77 amino acid residues and exists in multiple molecular forms, showing a widespread pattern of expression. Apelin has been reported to partially suppress cytokine production from mouse spleen and, specifically, to induce the promotion of extracellular acidification and inhibition of cAMP production in Chinese hamster ovary cells. Moreover, it is involved in the regulation of blood pressure and blood flow. Previous to the identification of apelin, APJ was considered an orphan G protein coupled receptor. The apelin receptor (both by immunohistochemistry and in situ) has been localized to the CNS and is currently thought to play a role in stress response, the intake of food and water and haemodynamic homeostasis. APJ expression has been reported in blood, brain, spinal cord, and vessel. ESTs have been isolated from brain, head/neck, lung, and placenta libraries. Because of its broad distribution the apelin receptor and its endogenous ligand may be involved in a wide range of biological process yet to be determined.

Antibody Tools for the Detection of APJ receptor

Acris Antibodies offers a range of antibodies for the detection of Apelin receptor in various applications.

Fig.1: Immunohistochemical staining with Apelin Receptor antibody SP4086P on human brain sections (blood vessel)

Fig.2: Immunohistochemical staining with Apelin Receptor antibody SP4067P on human brain sections (blood vessel)

Fig.3: Staining with Apelin Receptor antibody BP4014 on mouse brain cryosection

Fig.4: Staining with Apelin Receptor antibody MO15011X on human basal ganglia

Available Antibody Panel to APJ

Anti- Apelin Receptor (APJ, HG11, AGTRL) antibody

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