Acris Antibodies

Skip to Main Content »

Antibodies and related products for scientific research: primary antibodies: 143,053, secondary ab: 1,921, proteins: 35,423, kits: 594, lysates: 14,024, tissue slides: 1,687, other products: 3,247

You're currently on:

Antibodies to the Caveolin Family

Introduction

Caveolins are the principal protein components of caveolae, invaginations of the plasma membrane involved in cell signaling and trafficking.

Caveolins 1, 2 and 3 are a family of integral membrane proteins which are the principal components of caveolae membranes, organizing and concentrating caveolin-interacting proteins and lipids. Caveolins are proteins of about 20 kD. Caveolin-1 spans the plasma membrane twice forming a hairpin structure on the surface and forms homo- and heterooligomers with caveolin-2. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2. Caveolin-3 (Cav-3) or M-caveolin is the muscle-specific isoform of the caveolin family and mutations in the CAV3 gene lead to a large group of neuromuscular disorders.

Caveolins preferentially associate with inactive signalling molecules such as Src and Ras family proteins and have been proposed to act as a scaffold for the assembly of signalling complexes. Caveolin-1 colocalizes and associates with the integrin receptors in vivo. It regulates binding of the Src family kinases to the integrin receptors to promote adh esion and anchorage-dependent growth. Other proposed functions for caveolins include regulation of cell proliferation and tumor suppression.

Antibody Panel to Caveolins

Acris Antibodies offers a range of polyclonal antibodies for the detection of the three currently known caveolins. For caveolin 2 a phospho specific antibody is also available whose immunizing peptide corresponds to amino acid residues 14-25 from mouse phosphocaveolin-2 with tyrosine 19 being phosphorylated.

These antibodies can be used in Western blot, Immunoprecipitation and / or Immunofluorescence.

Fig.1: Western blot of caveolin 1 on rat heart protein extract using SP5142P. Fig.2: Western blot of caveolin 2 on rat skeletal muscle protein ext ract using SP5143P. Fig.3: Western blot detection of caveolin 3 from rat cardiac muscle protein extract using SP5144P.

Fig.1: Western blot of caveolin 1 on rat heart protein extract using SP5142P.

Fig.2: Western blot of caveolin 2 on rat skeletal muscle protein ext ract using SP5143P.

Fig.3: Western blot detection of caveolin 3 from rat cardiac muscle protein extract using SP5144P.

Antibody Panel to Caveolin Family

Caveolin 1-3, Caveolin 2 p-yr19 antibody.

Literature

Traverso M, Gazzerro E, Assereto S, Sotgia F, Biancheri R, Stringara S, Giberti L, Pedemonte M, Wang X, Scapolan S, Pasquini E, Donati MA, Zara F, Lisanti MP, Bruno C, Minetti C. Caveolin-3 T78M and T78K missense mutations lead to different phenotypes in vivo and in vitro. Lab Invest. 2008 Mar;88(3):275-83.

Volonte D, McTiernan CF, Drab M, Kasper M, Galbiati F. Caveolin-1 and caveolin-3 form heterooligomeric complexes in atrial cardiac myocytes that are required for doxorubicin-induced apoptosis. Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H392-401.

Insel PA, Head BP, Ostrom RS, Patel HH, Swaney JS, Tang CM, Roth DM. Caveolae and lipid rafts: g protein-coupled receptor signalling microdomains in cardiac myocytes. Ann NY Acad Sci. 2005 Jun; 1047: 166-72.

Li XA, Everson WV, Smart EJ. Caveolae, lipid rafts, and vascular disease. Trends Cardiovasc Med. 2005 Apr; 15(3): 92-6.

Found 28 items

Antibodies


Catalog No. Host Clone/Iso. Presentation   Reactivity Applications  
AP17924PU-N Caveolin-2 (N-term) antibody 
 Rabbit Hu E, WB 0.1 mg / 315 €
    Acris Antibodies GmbH
 
SP5138CP Caveolin-2 pTyr19 Control Peptide 
  Purified   50 µg / 180 €
    Acris Antibodies GmbH
 
SP5138P Caveolin-2 pTyr19 antibody 
 Rabbit Aff - Purified Hu, Ms, Rt IF, WB 0.1 mg / 380 €
    Acris Antibodies GmbH
 
SP5143CP Caveolin-2 Control Peptide 
  Purified   50 µg / 180 €
    Acris Antibodies GmbH
 
SP5143P Caveolin-2 antibody 
 Rabbit Aff - Purified Hu, Ms, Rt WB, IP 0.1 mg / 370 €
    Acris Antibodies GmbH
 
PC211 Caveolin-2 antibody 
 Rabbit Purified Hu WB 50 µg / 430 €
    Kamiya Biomedical Company
 
PC212 Caveolin-2 pSer23 antibody 
 Rabbit Purified Hu WB 50 µg / 610 €
    Kamiya Biomedical Company
 
PC213 Caveolin-2 pSer36 antibody 
 Rabbit Purified Hu WB 50 µg / 610 €
    Kamiya Biomedical Company
 
NB100-79911 Caveolin-2 pTyr27 antibody 
 Rabbit EP2221Y Hu WB, IP 0.1 ml / 400 €
  IgG   Novus Biologicals Inc.
 
NB120-3417 Caveolin-2 antibody 
 Rabbit Aff - Purified Ms IF, WB 0.1 mg / 340 €
  IgG   Novus Biologicals Inc.
 
NB300-586 Caveolin-2 antibody 
 Rabbit Aff - Purified Rt WB, IP 0.1 mg / 360 €
    Novus Biologicals Inc.
 
NB300-586PEP Caveolin-2 antibody 
    0.05 mg / 220 €
    Novus Biologicals Inc.
 
NBP1-31116 Caveolin-2 antibody 
 Rabbit Hu WB, Dot 0.1 ml / 390 €
  IgG   Novus Biologicals Inc.
 
NBP1-40643 Caveolin-2 antibody 
 Rabbit EPR2220 Hu C, IF, WB, IP 0.1 mg / 380 €
  IgG   Novus Biologicals Inc.
 
AVARP09020_P050 Caveolin-2 antibody 
 Rabbit Aff - Purified Hu   50 µg / 330 €
    AVIVA Systems Biology
 
AP08227PU-N Caveolin-3 (aa 19-41) antibody 
 Rabbit Aff - Purified Hu, Rt, Bov, Sh P, WB 50 µg / 360 €
  IgG   Acris Antibodies GmbH
 
AP16967PU-N Caveolin-3 (N-term) antibody 
 Goat Aff - Purified Hu, Ms, Rt, Bov, Can, Por WB 0.1 mg / 250 €
    Acris Antibodies GmbH
 
AP17187PU-N Caveolin-3 (N-term) antibody 
 Rabbit Hu E, WB 0.1 mg / 315 €
    Acris Antibodies GmbH
 
SP5144CP Caveolin-3 Control Peptide 
  Purified   50 µg / 180 €
    Acris Antibodies GmbH
 
SP5144P Caveolin-3 antibody 
 Rabbit Aff - Purified Hu, Ms, Rt WB, IP 0.1 mg / 370 €
    Acris Antibodies GmbH
 
NB110-5029 Caveolin-3 antibody 
 Rabbit Aff - Purified Hu, Ms, Rt C, P, WB, IP 0.1 mg / 360 €
  IgG   Novus Biologicals Inc.
 
NBP1-28917 Caveolin-3 antibody 
 Goat Aff - Purified Hu, Ms, Rt, Bov, Can, Por E, WB 0.1 mg / 360 €
  IgG   Novus Biologicals Inc.
 
NBP1-31235 Caveolin-3 antibody 
 Rabbit Hu WB, Dot 0.1 mg / 390 €
  IgG   Novus Biologicals Inc.
 
NBP1-35445 Caveolin-3 antibody 
 Rabbit Hu WB 0.1 ml / 380 €
  IgG   Novus Biologicals Inc.
 
NBP1-35446 Caveolin-3 antibody 
 Rabbit Hu WB 1.0 ml / 480 €
  IgG   Novus Biologicals Inc.
 
NBP1-39673 Caveolin-3 antibody 
 Rabbit Hu, Rt, Bov, Sh C, WB 0.05 mg / 410 €
  IgG   Novus Biologicals Inc.
 
AVARP09021_P050 Caveolin-3 antibody 
 Rabbit Aff - Purified Hu   50 µg / 330 €
    AVIVA Systems Biology
 
EB09304 Caveolin-3 (N-term) antibody 
 Goat Aff - Purified Hu, Ms, Rt, Bov, Can, Por WB 0.1 mg / 310 €
    Everest Biotech Ltd.