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Antibodies to the Caveolin Family

Introduction

Caveolins are the principal protein components of caveolae, invaginations of the plasma membrane involved in cell signaling and trafficking.

Caveolins 1, 2 and 3 are a family of integral membrane proteins which are the principal components of caveolae membranes, organizing and concentrating caveolin-interacting proteins and lipids. Caveolins are proteins of about 20 kD. Caveolin-1 spans the plasma membrane twice forming a hairpin structure on the surface and forms homo- and heterooligomers with caveolin-2. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2. Caveolin-3 (Cav-3) or M-caveolin is the muscle-specific isoform of the caveolin family and mutations in the CAV3 gene lead to a large group of neuromuscular disorders.

Caveolins preferentially associate with inactive signalling molecules such as Src and Ras family proteins and have been proposed to act as a scaffold for the assembly of signalling complexes. Caveolin-1 colocalizes and associates with the integrin receptors in vivo. It regulates binding of the Src family kinases to the integrin receptors to promote adh esion and anchorage-dependent growth. Other proposed functions for caveolins include regulation of cell proliferation and tumor suppression.

Antibody Panel to Caveolins

Acris Antibodies offers a range of polyclonal antibodies for the detection of the three currently known caveolins. For caveolin 2 a phospho specific antibody is also available whose immunizing peptide corresponds to amino acid residues 14-25 from mouse phosphocaveolin-2 with tyrosine 19 being phosphorylated.

These antibodies can be used in Western blot, Immunoprecipitation and / or Immunofluorescence.

Fig.1: Western blot of caveolin 1 on rat heart protein extract using SP5142P. Fig.2: Western blot of caveolin 2 on rat skeletal muscle protein ext ract using SP5143P. Fig.3: Western blot detection of caveolin 3 from rat cardiac muscle protein extract using SP5144P.

Fig.1: Western blot of caveolin 1 on rat heart protein extract using SP5142P.

Fig.2: Western blot of caveolin 2 on rat skeletal muscle protein ext ract using SP5143P.

Fig.3: Western blot detection of caveolin 3 from rat cardiac muscle protein extract using SP5144P.

Antibody Panel to Caveolin Family

Caveolin 1-3, Caveolin 2 p-yr19 antibody.

Literature

Traverso M, Gazzerro E, Assereto S, Sotgia F, Biancheri R, Stringara S, Giberti L, Pedemonte M, Wang X, Scapolan S, Pasquini E, Donati MA, Zara F, Lisanti MP, Bruno C, Minetti C. Caveolin-3 T78M and T78K missense mutations lead to different phenotypes in vivo and in vitro. Lab Invest. 2008 Mar;88(3):275-83.

Volonte D, McTiernan CF, Drab M, Kasper M, Galbiati F. Caveolin-1 and caveolin-3 form heterooligomeric complexes in atrial cardiac myocytes that are required for doxorubicin-induced apoptosis. Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H392-401.

Insel PA, Head BP, Ostrom RS, Patel HH, Swaney JS, Tang CM, Roth DM. Caveolae and lipid rafts: g protein-coupled receptor signalling microdomains in cardiac myocytes. Ann NY Acad Sci. 2005 Jun; 1047: 166-72.

Li XA, Everson WV, Smart EJ. Caveolae, lipid rafts, and vascular disease. Trends Cardiovasc Med. 2005 Apr; 15(3): 92-6.

 

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Antibodies


Catalog No. Clone/Isotype Presentation Reactivity Applications  
AP00380PU-N Caveolin-1 / CAV1 antibody  
  Aff - Purified Hu P 50 µg / US$ 515
Rabbit Acris Antibodies GmbH
 
AP00381PU-N Caveolin-1 / CAV1 antibody  
  Aff - Purified Hu P 50 µg / US$ 515
Rabbit Acris Antibodies GmbH
 
AP00382PU-N Caveolin-1 / CAV1 antibody  
  Aff - Purified Hu P 50 µg / US$ 515
Rabbit Acris Antibodies GmbH
 
AP02643PU-N Caveolin-1 / CAV1 antibody  
  Aff - Purified Ms, Hu, Rt WB 100 µg / US$ 375
Rabbit Acris Antibodies GmbH
 
AP02643PU-S Caveolin-1 / CAV1 antibody  
  Aff - Purified Ms, Hu, Rt WB 50 µg / US$ 275
Rabbit Acris Antibodies GmbH
 
SP5142P Caveolin-1 / CAV1 antibody  
  Aff - Purified Can, Hst, Ms, Rt IP, WB 0.1 mg / US$ 455
Rabbit Acris Antibodies GmbH
 
EB06817 Caveolin-1 / CAV1 antibody  
  Aff - Purified Can, Hu, Ms, Por, Rt WB 0.1 mg / ---
Goat Everest Biotech Ltd.
 
GTX17052 Caveolin-1 / CAV1 antibody  
  Rt IP, WB 50 µg / ---
Mouse IgG2b GeneTex Inc.
 
GTX40059 Caveolin-1 / CAV1 antibody  
  Aff - Purified Hu C 50 µg / ---
Rabbit GeneTex Inc.
 
GTX40062 Caveolin-1 / CAV1 antibody  
  Aff - Purified Hu C 50 µg / ---
Rabbit GeneTex Inc.
 
GTX40066 Caveolin-1 / CAV1 antibody  
  Aff - Purified Hu C 50 µg / ---
Rabbit GeneTex Inc.
 
GTX80909 Caveolin-1 / CAV1 antibody  
  Biotin Rt WB 100 µg / ---
Rabbit GeneTex Inc.
 
NB100-615 Caveolin-1 / CAV1 antibody  
  Purified Hu, Ms, Rt IF, IP, WB 0.2 mg / US$ 435
Mouse IgG2b Novus Biologicals Inc.
 
NB110-55670 Caveolin-1 / CAV1 antibody  
  Purified Hu, Ms F, IF, WB 0.1 ml / US$ 515
Rabbit IgG Novus Biologicals Inc.
 
NB300-509 Caveolin-1 / CAV1 antibody  
  Aff - Purified Hu, Can, Hst, Ms, Rt IP, WB 0.1 mg / US$ 485
Rabbit Novus Biologicals Inc.
 
GTX22910 Caveolin-1 / CAV1 (Caveolae Marker) antibody  
  Aff - Purified Hu, Rt, Ms, Hst IF, IP, WB 100 µg / ---
Rabbit IgG GeneTex Inc.
 
SP5142CP Caveolin-1 / CAV1 (Control Peptide)  
  Purified 50 µg / US$ 255
Acris Antibodies GmbH
 
AP02388PU-N Caveolin-1 / CAV1 (pTyr14) antibody  
  Aff - Purified Hu, Ms WB 100 µg / US$ 425
Rabbit Acris Antibodies GmbH
 
AP02388PU-S Caveolin-1 / CAV1 (pTyr14) antibody  
  Aff - Purified Hu, Ms WB 50 µg / US$ 325
Rabbit Acris Antibodies GmbH
 
SP5143P Caveolin-2 / CAV2 antibody  
  Aff - Purified Rt, Ms, Hu IP, WB 0.1 mg / US$ 455
Rabbit Acris Antibodies GmbH
 
GTX13542 Caveolin-2 / CAV2 antibody  
  Aff - Purified Hu WB 25 µg / ---
Rabbit IgG GeneTex Inc.
 
PC211 Caveolin-2 / CAV2 antibody  
  Purified Hu WB 50 µg / ---
Rabbit Kamiya Biomedical Company
 
NB120-13542 Caveolin-2 / CAV2 antibody  
  Aff - Purified WB 0.025 mg / US$ 565
Rabbit IgG Novus Biologicals Inc.
 
NB120-13544 Caveolin-2 / CAV2 antibody  
  Aff - Purified Hu WB 0.025 mg / US$ 565
Rabbit IgG Novus Biologicals Inc.
 
NB300-586 Caveolin-2 / CAV2 antibody  
  Aff - Purified Rt IF, IP, WB 0.1 mg / US$ 485
Rabbit Novus Biologicals Inc.
 
GTX22911 Caveolin-2 / CAV2 (Caveolae Marker) antibody  
  Aff - Purified Rt IP, WB 100 µg / ---
Rabbit IgG GeneTex Inc.
 
SP5143CP Caveolin-2 / CAV2 (Control Peptide)  
  Purified 50 µg / US$ 255
Acris Antibodies GmbH
 
GTX13543 Caveolin-2 / CAV2 (pSer23) antibody  
  Aff - Purified Hu WB 25 µg / ---
Rabbit IgG GeneTex Inc.
 
PC212 Caveolin-2 / CAV2 (pSer23) antibody  
  Purified Hu WB 50 µg / ---
Rabbit Kamiya Biomedical Company
 
GTX13544 Caveolin-2 / CAV2 (pSer36) antibody  
  Aff - Purified Hu WB 25 µg / ---
Rabbit IgG GeneTex Inc.
 
PC213 Caveolin-2 / CAV2 (pSer36) antibody  
  Purified Hu WB 50 µg / ---
Rabbit Kamiya Biomedical Company
 
SP5138P Caveolin-2 / CAV2 (pTyr19) antibody  
  Aff - Purified Ms, Rt, Hu IF, WB 0.1 mg / US$ 485
Rabbit Acris Antibodies GmbH
 
SP5138CP Caveolin-2 / CAV2 (pTyr19) Control Peptide  
  Purified 50 µg / US$ 255
Acris Antibodies GmbH
 
GTX23417 Caveolin-2 / CAV2 (pY19) antibody  
  Aff - Purified Ms, Rt, Hu IF, WB 100 µg / ---
Rabbit IgG GeneTex Inc.
 
H00000859-A01 Caveolin-3 / CAV3 antibody  
  Serum Hu WB 50 µl / ---
Mouse Abnova Taiwan Corp.
 
H00000859-M03 Caveolin-3 / CAV3 antibody  
  1G11 Purified Hu WB 100 µg / ---
Mouse IgG Abnova Taiwan Corp.
 
SP5144P Caveolin-3 / CAV3 antibody  
  Aff - Purified Rt, Ms, Hu IP, WB 0.1 mg / US$ 455
Rabbit Acris Antibodies GmbH
 
AVARP09021_P050 Caveolin-3 / CAV3 antibody  
  Aff - Purified Hu WB 50 µg / ---
Rabbit AVIVA Systems Biology
 
GTX22912 Caveolin-3 / CAV3 (Caveolae Marker) antibody  
  Aff - Purified Hu, Rt, Ms IP, WB 100 µg / ---
Rabbit IgG GeneTex Inc.
 
SP5144CP Caveolin-3 / CAV3 (Control Peptide)  
  Purified 50 µg / US$ 255
Acris Antibodies GmbH
 

Protein


Catalog No. Species Presentation Purity   Source  
H00000857-P01-10 Caveolin-1 / CAV1 antigen  
  Human in vitro transl. 10 µg / ---
      Abnova Taiwan Corp.
 
H00000857-P01-25 Caveolin-1 / CAV1 antigen  
  Human in vitro transl. 25 µg / ---
      Abnova Taiwan Corp.
 
GTX24928 Caveolin-1 / CAV1 antigen  
  50 µg / ---
      GeneTex Inc.
 
GTX24929 Caveolin-2 / CAV2 antigen  
  50 µg / ---
      GeneTex Inc.
 
GTX24962 Caveolin-2 / CAV2 antigen  
  50 µg / ---
      GeneTex Inc.
 
H00000859-Q01-10 Caveolin-3 / CAV3 antigen  
  Human in vitro transl. 10 µg / ---
      Abnova Taiwan Corp.
 
H00000859-Q01-25 Caveolin-3 / CAV3 antigen  
  Human in vitro transl. 25 µg / ---
      Abnova Taiwan Corp.
 
GTX24930 Caveolin-3 / CAV3 antigen  
  50 µg / ---
      GeneTex Inc.