Antibodies to FLIP/I-FLICE/Casper

Introduction

Fas-associated death domain (FADD) and caspase-8 are key signal transducers for death receptor-induced apoptosis; cellular Fas-associated death domain-like interleukin-1-beta converting enzyme (FLICE) inhibitory proteins (cFLIPs) are endogenous caspase homologues that inhibit programmed cell death. Interestingly, FADD and caspase-8 also play a role in T cell development and T cell receptor (TCR)-mediated proliferative responses.

Animal models have indicated that c-FLIP plays an important role in T cell proliferation and heart development. To date, three isoforms of human cytosolic FLIP (c-FLIP) and six viral homologs (v-FLIP) have been identified. Recently, the crystal structure of v-FLIP MC159 was determined for the first time as an atomic-detail FLIP structure, which revealed that two death effector domains are packed tightly against each other mainly through conserved hydrophobic interactions. Abnormal c-FLIP expression has been identified in various diseases such as multiple sclerosis (MS), Alzheimer's disease (AD), diabetes mellitus, rheumatoid arthritis (RA) and various cancers.

Antibody Panel to FLIP/I-FLICE

Acris Antibodies offers a range of polyclonal antibodies to FLICE inhibitory proteins useful for various applications.

Available Antibody Panel FLIP/I-FLICE/Casper

FLIP/I-FLICE, FLAME-1, CASH, CLARP –antibody.

Literature

Chau H, Wong V, Chen NJ, Huang HL, Lin WJ, Mirtsos C, Elford AR, Bonnard M, Wakeham A, You-Ten AI, Lemmers B, Salmena L, Pellegrini M, Hakem R, Mak TW, Ohashi P, Yeh WC. Cellular FLICE-inhibitory protein is required for T cell survival and cycling. J Exp Med. 2005 Aug 1; 202(3): 405-13.

Hainsworth AH, Bermpohl D, Webb TE, Darwish R, Fiskum G, Qiu J, McCarthy D, Moskowitz MA, Whalen MJ. Expression of cellular FLICE inhibitory proteins (cFLIP) in normal and traumatic murine and human cerebral cortex. J Cereb Blood Flow Metab. 2005 Aug; 25(8): 1030-40.

Micheau O. Cellular FLICE-inhibitory protein: an attractive therapeutic target Expert Opin Ther Targets. 2003 Aug; 7(4): 559-73.

Hu S, Vincenz C, Ni J, Gentz R, Dixit VM. I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD95-induced apoptosis. J Biol Chem. 1997 Jul 11; 272(28): 17255-7.

5. Yang JK. FLIP as an Anti-Cancer Therapeutic Target. Yonsei Med J. 2008 Feb;49(1):19-27.