Antibodies to Vascular Endothelial Growth Factor Receptor (VEGFR) Family: VEGFR-1, VEGFR-2 and VEGFR-3 antibody

Introduction

Within the last ten years arised strong evidence for the essential role of VEGF in vasculogenesis and angiogenesis. The development of blood vessels includes two processes. Vasculogenesis is the embryologic formation of blood islands, the earliest vascular system, by the differentiation from mesoderm of angioblasts and hemopoietic precursor cells. Angiogenesis is the sprouting of pre-existing vessels to form the vascular tree. In addition to a key role in embryological development, angiogenesis is essential for such things as wound healing and tumor growth.

While many growth factors exhibit angiogenic activity (FGFs, PDGF, TGF-alpha and HGF), most evidence points to a special role for VEGF. VEGF is a dimeric glycoprotein that stimulates endothelial cells, induces angiogenesis and increases vascular permeability.

The receptors for VEGF are VEGFR-1 (or Flt-1) and VEGFR-2 (or KDR in humans and Flk-1 in mice). Homozygous mutants of the VEGF receptors led to lack of vasculogenesis and death of mouse embryos at about day 8, indicating that VEGF receptors are essential for formation of a normal vasculature. In addition to VEGF (VEGF-A) there exist three VEGF family members VEGF-B, VEGF-C and VEGF-D. Less is known about the function and regulation of VEGF-B, -C, and -D, but they do not seem to be regulated by the major pathways that regulate VEGF-A. VEGF-C and D are ligands for KDR/Flk-1 but also for the third VEGF Receptor VEGFR-3 (FLT4 / flt-4), whereas VEGF-B binds only to Flt-1.

Like other growth factor receptors, upon ligand binding VEGFR2 dimerizes and is autophosphorylated on multiple tyrosine residues. These phosphotyrosine sites are involved in regulation of intrinsic tyrosine kinase activity or serve as binding sites for SH2 domains and phosphotyrosine binding (PTB) domains of downstream signaling proteins.

Antibody tools for Detection of to VEGF receptors

Acris Antibodies offers a set of monoclonal and polyclonal antibodies to VEGF-Receptors (VEGFR) for use in Western blotting, immunohistochemistry and other immunological detection methods like immunofluorescence microscopy or flow cytometry, ELISA or immunoprecipitation.

Available antibody panel to VEGF Receptors

VEGFR-1 (VEGF-R1 / FLT-1 / flt1), VEGFR-2 (VEGF-R2, FLK-1 / KDR), phosphorylated VEGF Receptor 2, VEGFR-3 antibody (VEGF-R3, FLT-4 / flt4)

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