Antibody panel to Epithelial Cell Adhesion Molecule (EpCAM)

Introduction

Epithelial Cell Adhesion Molecule (EpCAM) is a 40kD cell surface antigen. This antigen has been identified independently by a number of groups, and has been known by a variety of names (CD326, KSA, ESA, Lymphocyte antigen 74, M1S2, M4S1, GA733 2, MIC18, MK1, TACSTD1, TROP1).

Several monoclonal antibodies have been raised against EpCAM, many of which have been described as tumour specific molecules on carcinomas. EpCAM is a Type 1 transmembrane glycoprotein. It is expressed on the basolateral membrane of cells by the majority of epithelial tissues, with the exception of adult squamous epithelium and some specific epithelial cell types including hepatocytes and gastric epithelial cells. EpCAM expression has been reported to be a possible marker of early malignancy, with expression being increased in tumour cells, and de novo expression being seen in dysplastic squamous epithelium.

Antibody Panel to Epithelial Cell Surface Antigen Ep-CAM

Acris Antibodies offers a full range of antibodies for specific detetction of EpCAM using western blotting or immunohistochemistry. For staining pictures see gallery below.

Fig.1: Staining of human breast carcinoma tissue using anti Ep-CAM monoclonal antibody DM406 clone Ber-EP4

Fig.2: Staining of human colon carcinoma tissue using anti Ep-CAM monoclonal antibody DM2014S clone MOC-31

Fig.3: Staining of human breast carcinoma tissue using anti Ep-CAM monoclonal antibody NB600-1182 clone AUA1

Available Antibody Panel to ep-CAM

Anti- CD326, KSA, ESA, Lymphocyte antigen 74, M1S2, M4S1, GA733 2, MIC18, MK1, TACSTD1, TROP1 antibody