FocusOn
124
IntroductionFOX transcription factors are characterized by the FOX domain, which is an ~100-amino-acid monomeric DNA binding domain. The three-dimensional structure of FOX domain consists of two W1 and W2 loops (or wings) and three helices. Due to the butterfly-like appearance, FOX domain is also known as ‘winged-helix’ domain.Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1,… Read more
Available products: 183
125
Antibody Panel to Epithelial Cell Surface Antigen EpCAMAcris Antibodies offers a full range of thoroughly evaluated antibodies for specific detection of EpCAM using Western blotting and immunohistochemistry methods, and also other immunological applications, such as immunocytochemistry and immunoprecipitation (see Product list).IntroductionEpithelial cell adhesion molecule (EpCAM) is a 40kD cell surface antigen. This antigen has been identified independently… Read more
Available products: 21
128
IntroductionAutophagy is a highly conserved cellular degradation process. In this degradation pathway in mammalian cells constituents of cytosol and organelles are sequestered into a double-membrane vesicle and delivered into the lysosome. This results in breakdown and eventual recycling of the resulting macromolecules. In eukaryotic cells autophagy is divided into three major mechanistically different pathways: Macroautophagy is a catabolic process… Read more
Available products: 43
129
Selected Antibody Tools for the Detection of p53 and p53 Interacting ProteinsAcris Antibodies offers a wide range of antibodies to p53 and p53 interacting proteins for various applications like Immunoprecipitation, Immunohistochemistry, ELISA or Western blotting (including phospho-specific antibodies). P53 control peptides are also available (see Product list).p53Cellular tumor antigen p53 is also called tumor protein p53 (TP53) or transformation-related… Read more
Available products: 66
130
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia that generally initiates with subtle failure of memory, progressing over years to an incapacitating level. Approximately 25 % of all AD is familial of which approximately 95 % is late-onset (age >60-65 years) and 5 % is early-onset (age Read more
Available products: 102
131
Parkinson's disease (PD) is a chronic, progressive neurodegenerative disorder of the central nervous system characterized by tremor, muscle rigidity, postural abnormalities and slowed movement (bradykinesia), with dementia manifesting in 20 % of the afflicted. Onset before age 20 is categorized as juvenile-onset, before age 50 as early-onset and after age 50 as late-onset PD. After Alzheimer's disease, PD is the second most common neurodegenerative… Read more
Available products: 54
132
Note: This FocusOn supersedes FocusOn 11 (“Antibody Panel to Huntingtin and Huntingtin Interacting Protein (HIP1, HIP2, HIP14)”)Huntington’s disease (HD) is a fatal neurodegenerative disorder which usually occurs in mid-age. It is characterized by psychiatric disorders, involuntary movements and dementia, leading to death within 10-20 years.HuntingtinHuntingtin is a 350 kDa protein that is altered in HD. The expanded trinucleotide CAG repeat… Read more
Available products: 18
133
Amyotrophic Lateral Sclerosis (ALS) is described as a neurodegenerative disease and characterized by degeneration of upper and lower motor neurons. ALS is specified by mid-to-late-life onset, selective neuronal death and the formation of protein deposits in affected neuronal tissues similar to other neurodegenerative diseases (Alzheimer's disease: FocusOn 130, Parkinson's disease: FocusOn 131, Huntington's disease: FocusOn 132). Sporadic cases of… Read more
Available products: 11
