FocusOn
011
Huntingtin is a 350 kDa protein of 3144 amino acids that is altered in Huntington's disease (HD). The expanded trinucleotide CAG repeat of the HD gene encodes an abnormally expanded polyglutamine stretch in the N-terminus of the Huntingtin protein. The normal function of Huntingtin still remains uncertain but it has been suggested that it performs a necessary housekeeping function. The abnormal form of Huntingtin aggregates in vitro and forms neuronal… Read more
Available products: 14
012
Introduction Growth cones are specialised sensory structures located at the tip of neurites, which are involved in the mechanism that enables elongation and navigation of axons during neuronal development. Growth cone motility depends on cytoskeletal dynamics. The two major cytoskeletal components in growth cones are actin filaments, which are predominantly located in the peripheral (P)-domain, and microtubules in the central (C)-domain. Spatially… Read more
Available products: 2
013
IntroductionGlucose is an important source of energy for all living cells. Glucose is transported across the cells by a family of energy-dependent and Na+-dependent Glucose co-transporters (SGLTs) and by facilitative glucose transporters (Gluts or SLC2A family). Molecular cloning of SGLTs has identified a family of closely related genes that encodes at least 14 proteins (Glut1 - Glut14).The kidneys play a major role in the regulation of glucose levels.… Read more
Available products: 10
014
ICOS (CD278, AILIM, CRP-1, Inducible T-cell costimulator) enhances T-cell responses to foreign antigens, participating in the stimulation of proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and antibody secretion by B-cells. ICOS is critical in fostering T/B-cells interaction and for normal antibody responses to T-cell dependent antigens. Other immune response roles for ICOS include superinduction… Read more
Available products: 7
015
IntroductionThe Calcitonin receptor plays an important role in the regulation of calcium and phosphate metabolism. It binds the peptide hormone Calcitonin, wich was named for its ability to reduce the blood calcium level.Calcitonin (CT) is a 32 amino acid peptide cleaved from a larger prohormone. It contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. All members of the calcitonin family of peptides share… Read more
Available products: 13
016
Most mammalian cells transport glucose through a family of membrane proteins known as glucose transporters (Glut or SLC2A family / solute carrier family 2). Molecular cloning of these glucose transporters has identified a family of closely related genes. Individual members of this family have identical predicted secondary structures with 12 transmembrane domains. Both N and C-termini are predicted to be cytoplasmic. There is a large extracellular… Read more
Available products: 17
017
Introduction Growth hormone (GH), controls body growth, carbohydrate-protein-lipid metabolism and water-electrolyte balance. GH-release is stimulated by the GH-releasing hormone (GHRH) and inhibited by somatostatin. GH secretagogues (GHSs) are synthetic compounds that are potent stimulators of GH release. Special GHSs, working through a novel orphan G-protein-coupled receptor (GPCR), the GHS receptor (GHS-R) have emerged as strong regulators of GH… Read more
Available products: 6
018
TWEAK is a type II transmembrane TNF superfamily member with high identity to TNF in its extracellular portion (Tumor necrosis factor ligand superfamily member 12, gene name TNFSF12). The TWEAK transcript is expressed broadly in many adult and fetal tissues, however, the staining of human peripheral blood mononuclear cells with monoclonal antibodies shows a more restricted pattern. While freshly isolated PBMCs do not express detectable levels of TWEAK… Read more
Available products: 11
019
IntroductionProtein PD-1 (programmed death-1, also known as CD279, gene name PDCD1) is a 55 KDa member of the immunoglobulin superfamily. It contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. PD-1 is expressed predominantly on activated T and B lymphocytes.Two members of the B7 family have been identified as the PD-1 ligands, PD-L1 (B7-H1, CD274) and PD-L2… Read more
Available products: 31
020
Introduction Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. It most commonly occurs in wild and domestic mammalians (cattle, sheep etc.) in agricultural regions, including Southern and Eastern Europe. Humans can be infected with anthrax by handling products from infected animals or by inhaling anthrax spores from contaminated animal products. B. anthracis spores can survive in the soil for many years… Read more
Available products: 10
