Antibodies to Prolactin Receptor - FocusOn 048
Introduction: Prolactin (PRL) is a hormone involved in a variety of important functions including ion transport and osmoregulation, stimulation of milk, protein synthesis as well as the regulation of numerous reproductive functions.
PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor, a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. The PRL receptor consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.
Tools for the Detection of Prolactin Receptor
Acris Antibodies offers a panel of antibodies to PRL receptor, suitable for immunological detection methods like immunohistochemistry, immunofluorescence microscopy or Western blotting. Recombinant Prolactin receptor is also available.
Fig. 1 illustrates immunohistochemical staining of PRL receptor in rat Islets of Langerhans using antibody SM5033P.
Fig. 2 illustrates immunohistochemical staining of PRL receptor in NB2 cells using antibody SM5034P.
Available antibody panel to Prolactin Receptor
Prolactin receptor (PRL receptor, PRLR) antibody