Antibody Panel to Chemokine Receptor Family - FocusOn 007
CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCR10, CCR11, CCXCR1, CCR D-6, CCRL1, CCRL2 and CXCR1 antibody, CXCR2, CXCR3, CXCR4, CXCR5, CXCR6 as well as CX3CR1 antibody
Chemokines and their receptors play a pivotal role in lymphocyte trafficking, recruiting and recirculation. They act through seven transmembrane G protein-coupled receptors. The chemokine system is increasingly recognized to play an important role in lymphocyte biology. Chemokine receptors are G-protein-coupled receptors (GPCRs) with seven transmembrane (TM7) spanning a-helices belonging to the rhodopsin superfamily. They have an N-terminus outside the cell, three extracellular domains, three intracellular loops and a C-terminus in the cytoplasm wich contains serine and threonine phosphorylation sides. These receptors bind their corresponding ligands with high affinity. Unusualy for members of the TM7 receptor superfamily nearly all chemokine receptors have multiple high-affinity ligands for a single receptor. CCR5 for example binds CCL3 and CCL4 as well as CCL5. Binding of a chemokine to its specific receptor on the cell surface activates a G-protein coupled signal transduction cascade. Finally the activation of protein kinases results in chemotaxis towards the source of the chemokine. Based on their ligand specificity, chemokine receptors can be divided into two major groups, CXCR and CCR, based on the two major classes of chemokines. Thus far six CXC receptors, one CX3C and twelve CC receptors have been identified.
Antibody Tools for Detection of Chemokine Receptors
Since Acris Antibodies was founded in 1998 we have increased the numbers of antibodies to chemokines and their receptors every year. Today we can offer an abundant antibody panel to chemokine receptors for various applications like Western blotting, immunohistochemistry, immunofluorescence, flow cytometry and other immunological detection methods.
Staining of human tonsil using anti CXCR3 antibody SP4005P showing Dendritic Cells, Macrophages and Lymphocytes.
Staining of human brain section using anti CXCR4 antibody SP4006P showing Neurons and Glia.
Staining of a Colon section (Ulcerative Colitis, Crypt Abscess) using anti CCR1 antibody SP4001P
Staining of human skin section using anti CCR6 antibody SP4022P
Available antibody panel to Chemokine Receptor groups CXCR and CCR
CXCR1 antibody (IL-8 Receptor alpha chain antibody / CD181a antibody), CXCR2 antibody (IL-8 Receptor beta chain antibody / CD182b antibody), CXCR3 antibody, CXCR4 antibody (SDF Receptor antibody / Fusin antibody / CD184 antibody), CXCR5 antibody, CXCR6 antibody (Bonzo antibody), CX3CR1 antibody (Fractalkine Receptor antibody), CCXCR1 antibody (Chemokine (C motif) XC Receptor 1 antibody), CCR1 antibody, CCR2 antibody, CCR3 antibody, CCR4 antibody, CCR5 antibody (CD195 antibody), CCR6 antibody, CCR7 antibody (CD197 antibody), CCR8 antibody, CCR9 antibody, CCR10 antibody, CCR11 antibody, CCR D-6 antibody, CCRL1 antibody (Chemokine (C-C motif) Receptor-like 1 antibody), CCRL2 antibody (Chemokine (C-C motif) Receptor-like 2 antibody).
1. Rossi, D and Zlotnik, A (2000) The biology of chemokines and their receptors. Annu Rev Immunol. 18, 217-242, PubMed ID 20297045
2. Bagglioni, M. (1998) Chemokines and leukocyte traffic. Nature 392, 565-568 PubMed ID 98219079
For detailed background information on Chemokines and their receptors visit Horst Ibelgaufts\' COPE: Cytokines Online Pathfinder Encyclopaedia at www.copewithcytokines.de