Antibody Panel to Thyroid Hormone Receptor (TR) - FocusOn 062

Introduction

Thyroid hormone receptors (TR) are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences called hormone response elements following activation by the appropriate hormone.

Thyroid hormones, through their interaction with TR, effect metabolic processes, growth and development in many tissues by regulating the expression of genes for growth hormone, malic enzyme and several hepatic proteins. There are two forms of TR; TR alpha (on chromosome 17) and TR beta (on chromosome 3). Each of these isoforms also has two isoforms; TR alpha-1 and TRv alpha-2, and TR beta-1 and TR beta-2 respectively. TR alpha-1 and 2 are identical through amino acid 370 where their sequences diverge. TRv alpha-2, which does not bind T3 and is a strong negative regulator of the functional TR, is 80 amino acids longer than TR alpha-1.

Antibody Tools for the Detection of Thyroid Hormone Receptor Subtypes

A panel of monoclonal and polyclonal antibodies for detection of Thyroid Hormone Receptor is available at Acris Antibodies. These antibodies are suitable for several immunological applications including immunohistochemistry on paraffin embedded sections.

Fig. 1: Formalin fixed paraffin embedded human colon carcinoma stained with THR a1/a2 antibody DP149 using ABC and AEC chromogen.

Available Antibody Panel to Thyroid Hormone Receptor

Anti- Thyroid Hormone Receptor (TR), TR alpha (THRA), TR alpha 1, TR alpha 2, TR beta (THRB) antibody