Antibodies to NPY Receptors (NPYR) - FocusOn 001

Introduction

Neuropeptide Y (NPY) is a neuropeptide colocalized and abundantly released with the neurotransmitter norepinephrine in the nervous system. It is synthesized by the postnatal olfactory epithelium of sustentacular cells. It promotes the proliferation of postnatal neuronal precursor cells and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion and potent vasoactive effects on the cardiovascular system.

Neuropeptide Y family of peptides signal through a family of G protein-coupled receptors present in the brain and sympathetic neurons. These NPY receptors (Y1-Y6) recognize NPY and related peptides.

Antibody Tools for detections of NPY Receptors Type 1 – 5

Acris Antibodies offers an thoroughly validated antibody panel to NPY receptors. These antibodies are useful for the detection of Neuropeptide Y Receptors by Western blotting; most of them can be used in immunohistochemical methods.

NPY1R

Fig. 1: NPY1R Polyclonal Antibody.
Fig. 1: NPY1R Polyclonal Antibody Cat.-No. AP23327PU-N.
Fig. 2: SP4420P NPY1R antibody immunohistochemical staining of Brain.
Fig. 2: SP4420P NPY1R antibody immunohistochemical staining of Brain.

NPY2R

Fig. 3: NPY Y2 receptor immunoreactivity in Mouse dorsal root ganglion of wild type (A) and NPY Y2 receptor Knockout (B) animals. Note that unspecific staining is observed in thick, possibly myelinated fibers. Image courtesy of Dr. Tomas Hökfelt, Karolinska Institute.
Fig. 3: NPY Y2 receptor immunoreactivity in Mouse dorsal root ganglion of wild type (A) and NPY Y2 receptor Knockout (B) animals. Note that unspecific staining is observed in thick, possibly myelinated fibers. Image courtesy of Dr. Tomas Hökfelt, Karolinska Institute (Cat.-No. AP20012PU-N).
Fig. 4: AP16644PU-N NPY2R antibody staining of Rat Brain lysate at 0.1 µg/ml (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Fig. 4: AP16644PU-N NPY2R antibody staining of Rat Brain lysate at 0.1 µg/ml (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

NPY4R

Fig. 5: Immunohistochemical staining of Brain using anti- PPYR4 antibody SP4422P
Fig. 5: Immunohistochemical staining of Brain using anti- PPYR1 antibody SP4422P.
Fig. 6: Immunohistochemical staining of Brain using anti- PPYR4 antibody SP4421P.
Fig. 6: Immunohistochemical staining of Brain using anti- PPYR1 antibody SP4421P

Available antibodies to NPY Receptor

Neuropeptide Y Receptor 1 antibody (NPY1R), Neuropeptide Y Receptor 2 (NPY2R), Neuropeptide Y Receptor 4 (NPY4R) and Neuropeptide Y Receptor 5 (NPY5R)

 

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  
AP01221PU-N

NPY receptor 1 / NPY1R antibody

Western blot (WB) analysis of NPY1-R antibody (Cat.-No.: AP01221PU-N) in extracts from NIH-3T3 cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH
AP23327PU-N

NPY receptor 1 / NPY1R (C-term) antibody

NPY1R Polyclonal Antibody
Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH
SP4420P

NPY receptor 1 / NPY1R antibody

SP4420P NPY1R antibody immunohistochemical staining of Brain Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €380.00
  Acris Antibodies GmbH
24506

NPY receptor 1 / NPY1R (356-382) antibody

Staining with Neuropeptide Y Y1 Receptor Antibody (24506)
Rabbit Serum Frog, GP, Hu, Ms, Rt C, ICC/IF
0.1 ml / €410.00
  ImmunoStar Inc.
AP16644PU-N

NPY receptor 2 / NPY2R antibody

AP16644PU-N NPY2R antibody staining of Rat Brain lysate at 0.1 µg/ml (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Ms, Rt E, IP, WB
0.1 mg / €270.00
  Acris Antibodies GmbH
AP20012CP-N

NPY receptor 2 / NPY2R Control Peptide

NPY receptor 2 / NPY2R Purified
0.1 mg / €140.00
  Acris Antibodies GmbH
AP20012PU-N

NPY receptor 2 / NPY2R antibody

NPY Y2 receptor immunoreactivity in Mouse dorsal root ganglion of wild type (A) and NPY Y2 receptor Knockout (B) animals.  Note that  unspecific staining is observed in thick, possibly myelinated fibers.  Image courtesy of Dr. Tomas Hökfelt, Karolinska Institute.
Rabbit IgG Aff - Purified Ms, Rt C, ICC/IF
0.1 ml / €390.00
  Acris Antibodies GmbH
AP20012PU-S

NPY receptor 2 / NPY2R antibody

NPY Y2 receptor immunoreactivity in Mouse dorsal root ganglion of wild type (A) and NPY Y2 receptor Knockout (B) animals.  Note that  unspecific staining is observed in thick, possibly myelinated fibers.  Image courtesy of Dr. Tomas Hökfelt, Karolinska Institute.
Rabbit IgG Aff - Purified Ms, Rt C, ICC/IF
50 µl / €250.00
  Acris Antibodies GmbH
AP20013SU-N

NPY receptor 2 / NPY2R (N-term + C-term) antibody

Figure 1. NPY Y2R staining of Rat cortex using Cy3-conjugated Donkey anti-Rabbit secondary antibodies (Red color) and DAPI (Blue) as a nuclear counterstain.
Rabbit IgG Serum Ms, Rt C, ICC/IF
0.1 ml / €370.00
  Acris Antibodies GmbH
SP4421P

NPY receptor 4 / NPY4R antibody

Immunohistochemical staining of Brain using anti- PPYR1 antibody SP4421P Rabbit Aff - Purified Hu P
50 µg / €380.00
  Acris Antibodies GmbH
SP4422P

NPY receptor 4 / NPY4R (C-term) antibody

Immunohistochemical staining of Brain using anti- PPYR1 antibody SP4422P Rabbit Aff - Purified Hu P
50 µg / €380.00
  Acris Antibodies GmbH
AP01324PU-N

NPY Receptor 5 / NPY5R antibody

Western blot (WB) analysis of NPY5-R antibody (Cat.-No.: AP01324PU-N) in extracts from COLO/Jurkat/HepG2 cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH
AP16374PU-N

NPY Receptor 5 / NPY5R antibody

AP16374PU-N NPY5R antibody  staining of Human Brain lysate at 0.3 µg/ml (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, IP, P, WB
0.1 mg / €270.00
  Acris Antibodies GmbH
AP31755PU-N

NPY Receptor 5 / NPY5R antibody

Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €380.00
  Acris Antibodies GmbH

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