Antibodies to P450 Aromatase - FocusOn 003

The aromatase complex consists of the CYP19 gene product aromatase cytochrome P450 (P450arom) and a flavoprotein NADPH-cytochrome P450 reductase. The aromatase complex is located in the endoplasmic reticulum of oestrogen-producing cells and catalyses the biosynthesis of oestrogens from androgens.

Oestrogens are known to play a major role in the development of breast cancer. Recent research suggests that abnormal expression of aromatase in breast cells, and surrounding stromal tissue, may influence breast tumour growth and maintenance. Inhibition of aromatase is considered to be an important approach for reducing growth stimulatory effects of oestrogens in hormone-dependent breast cancer. Effective aromatase inhibitors have been developed as therapeutic agents and are now widely used in treatment protocols for oestrogen-dependent breast cancer.

Aromatase has also been reported to have roles in male brain determination and masculine sexual behaviour. Oestrogen formed perinatally from testicular androgen, during steroid-sensitive phases in the brain during development, is reported to be involved in the irreversible determination of male brain development. A male differentiated brain has an enhanced responsiveness to hormonal activation of male-typical sexual behaviours by testosterone. The effects of testosterone on behaviour depend to a large extent upon its cellular conversion to oestrogen by P450arom. Androgen regulated levels of aromatase activity within the brain circuitry that mediate male sexual behaviour are greater in males than in females.

Acris Antibodies offers an antibody panel to Aromatase. These antibodies are valuable tools for studying the role of oestrogens and aromatase in health and disease by using Western blotting or immunohistochemistry.

Staining on formalin-fixed, paraffin-embedded tissue sections of human Placenta using Aromatase antibody AP00001PU-N showed staining of trophoblasts

Staining on formalin-fixed, paraffin-embedded tissue sections of human Placenta using Aromatase antibody AP00001PU-N showed staining of trophoblasts

 
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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  
AP00001PU-N

Aromatase antibody

Immunohistochemical staining of human placenta using Aromatase antibody AP00001PU-N showed staining of trophoblasts (Placental Villi 40X). Rabbit Purified Bov, Chk, Eq, Hu, Ms, Por, Rb, Rt, Sh P, WB
0.1 mg / €390.00
  Acris Antibodies GmbH
SM2222P

Aromatase (376-390) antibody

Staining of FFPE Human placenta with Aromatase (10x and 40x) Antibody Cat.-No SM2222PS (Clone H4) at 1/100 dilution. Antibody positive in the cell membrane of epithelial cells. Mouse IgG2a H4 Supernatant Bab, Bov, Chk, Eq, Gt, Hu, Marmoset, Mky, Ms, Por, Rb, Rt, Sh ICC/IF, P, WB
1 ml / €820.00
  Acris Antibodies GmbH
SM2222PS

Aromatase (376-390) antibody

Staining of FFPE Human placenta with Aromatase (10x and 40x) Antibody Cat.-No SM2222PS (Clone H4) at 1/100 dilution. Antibody positive in the cell membrane of epithelial cells. Mouse IgG2a H4 Supernatant Bab, Bov, Chk, Eq, Gt, Hu, Marmoset, Mky, Ms, Por, Rb, Rt, Sh ICC/IF, P, WB
0.2 ml / €220.00
  Acris Antibodies GmbH
SM2222PT

Aromatase (376-390) antibody

Staining of FFPE Human placenta with Aromatase (10x and 40x) Antibody Cat.-No SM2222PS (Clone H4) at 1/100 dilution. Antibody positive in the cell membrane of epithelial cells. Mouse IgG2a H4 Supernatant Bab, Bov, Chk, Eq, Gt, Hu, Marmoset, Ms, Por, Rb, Rt, Sh ICC/IF, P, WB
50 µl / €80.00
  Acris Antibodies GmbH
AP14030CP-N

Aromatase Control Peptide

Aromatase
0.1 mg / €120.00
  Acris Antibodies GmbH
AP14030PU-N

Aromatase (Center) antibody

AP14030PU-N CYP19A1 antibody staining of HL60 cell line lysates by Western blot (35 µg/lane). CYP19A1 (arrow) was detected using the purified antibody at 1/60 dilution. Rabbit Ig Purified Hu WB
0.4 ml / €340.00
  Acris Antibodies GmbH
AP14221CP-N

Aromatase Control Peptide

Aromatase
0.1 mg / €120.00
  Acris Antibodies GmbH
AP14221PU-N

Aromatase (C-term) antibody

Western blot analysis using AP14221PU-N CYP19A1 antibody in Jurkat cell line lysates (35 µg/lane). CYP19A1 (arrow) was detected using the purified antibody at 1/60 dilution. Rabbit Ig Purified Hu P, WB
0.4 ml / €340.00
  Acris Antibodies GmbH
AP16724PU-N

Aromatase antibody

AP16724PU-N Aromatase antibody staining of Human Placenta lysate at 0.1 µg/ml (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu P, WB
0.1 mg / €270.00
  Acris Antibodies GmbH
AP54875SU-N

Aromatase antibody

Aromatase Rabbit Serum C, E, WB
0.2 ml / €380.00
  Acris Antibodies GmbH
AP55401SU-N

P450 Aromatase (Cyp19a1a) antibody

P450 Aromatase (Cyp19a1a) Rabbit Serum Ze C, E, P, WB
0.2 ml / €380.00
  Acris Antibodies GmbH

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