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Regulators of G-Protein Signaling - FocusOn 111

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The Regulators of G-Protein Signaling (RGS) play a key role in the regulation of signal transduction by GPCRs (G-Protein coupled Receptors). They represent a protein family, who share a characteristic RGS domain. By this domain RGS proteins bind directly to activated G-alpha subunits and so function as GAPs  (GTPase−activating Proteins). Most RGS proteins are able to function as GAPs for different isoforms of G-alpha and so have influence on multiple signaling pathways. RGS proteins may however also show extreme specificity towards single signaling pathways.

RGS proteins may be regulated in their GAP activity or in their subcellular distribution. This is done by phopsphorylation, palmitoylation or through interaction with protein or lipid ligands. Many RGS proteins have GAP-independent functions, which influence the GPCR- and non-GPCR-mediated signal transduction, and so function as effector regulator or as effector itself. For this reason RGS proteins can be thought of as multifunctional regulators of signal transduction.

Antibodies to RGS

Acris Antibodies offers a large panel of antibodies for detection of RGS proteins in Western blot. Many antibodies are also reactive with RGS from mouse and rat and some have been tested successfully on paraffin sections (see pictures below).



Fig. 1a: RGS6 Staining IHC(P) on human kidney tissue using RGS6 antibody ARP34043. Arrows indicate RGS6-positive epithelial cells of renal tubuli.Fig. 1b: RGS13 Staining IHC(P) on human kidney tissue using RGS13 antibody ARP34051. Arrows indicate RGS13 positive epithelial cells.
Fig. 1a:  RGS6 Staining IHC(P) on human kidney tissue using RGS6 antibody ARP34043. Arrows indicate RGS6-positive epithelial cells of renal tubuli.

Fig. 1b:  RGS13 Staining IHC(P) on human kidney tissue using RGS13 antibody ARP34051. Arrows indicate RGS13 positive epithelial cells.



Literature

Hendriks-Balk MC, Peters SL, Michel MC, Alewijnse AE. Regulation of G protein-coupled receptor signalling: focus on the cardiovascular system and regulator of G protein signalling proteins. Eur J Pharmacol. 2008 May 13;585(2-3):278-91.

Jean-Baptiste G, Yang Z, Greenwood MT. Regulatory mechanisms involved in modulating RGS function. Cell Mol Life Sci. 2006 Sep;63(17):1969-85.

Available Antibody Panel for Regulators of G-Protein Signalling

Anti- RGS1 (1R20, BL34), RGS2 (G0S8), RGS3 (RGP3), RGS4 (RGP4), RGS5, RGS6 (S914), RGS7, RGS8, RGS9, RGS10, RGS11, RGS12, RGS13, RGS14, RGS16 (RGSR), RGS17, RGS18 (RGS13), RGS19 (GAIP, GNAI3IP), RGS20 (RGSZ1, ZGAP1) -antibody

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Antibodies

Catalog No. Host Clone/Iso. Pres.   React. Applications  
10678-1-AP

RGS2 antibody

Immunohistochemistry of paraffin-embedded Pancreas cancer using 10678-1-AP(RGS2 Antibody) at Dilution 1:50 (under 10x lens) Rabbit Aff - Purified Hu E, P, WB
0.15 ml / €255.00
  IgG   ProteinTech Group, Inc.
+1 additional image
 
AP07203PU-N

RGS2 antibody

Western blot analysis of RGS2 in human heart lysate using RGS2 antibody Cat.-No. AP07203PU-N at 2 ug/ml. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €380.00
  IgG   Acris Antibodies GmbH
+1 additional image
 
SP7361P

RGS2 antibody

Western bot analysis of RGS2 in human heart lysate using SP7361P at 2 µg/ml. Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €300.00
    Acris Antibodies GmbH
 
NB300-365

RGS2 antibody

RGS2 Chicken Aff - Purified Hu, Ms, Rt ICC/IF, WB
50 µg / €430.00
    Novus Biologicals Inc.
 
ARP42827_T100

RGS2 antibody

RGS2 Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rt WB
0.1 mg / €290.00
    AVIVA Systems Biology
 
AP00088PU-N

RGS3 antibody

Western blot analysis of RGS3 in transfected HEK293 cells (right lane). The left lane is mock control. Rabbit Purified Hu IP, WB
0.1 mg / €320.00
    Acris Antibodies GmbH
 
NB120-2564

RGS3 antibody

Western Blot: RGS3 Antibody [NB120-2564] - Western blot analysis of RGS3 in transfected HEK293 cells (right lane). The left lane is mock control. Rabbit Aff - Purified Hu IP, WB
0.1 mg / €390.00
  IgG   Novus Biologicals Inc.
 
AVARP09007_P050

RGS3 antibody

RGS3 Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €330.00
    AVIVA Systems Biology
+1 additional image
 
AVARP09007_T100

RGS3 antibody

RGS3 Rabbit Aff - Purified Chk, Hu, Ms, Rt
0.1 mg / €290.00
    AVIVA Systems Biology
 
TP372

RGS3 antibody

RGS3 Rabbit Purified Hu IP, WB
0.2 mg / €370.00
    Torrey Pines Biolabs
 
NB120-14264

RGS4 antibody

Linear Protein Map with Immunogenic Epitope Marked Chicken Aff - Purified Hu, Ms, Rt ICC/IF, WB
50 µg / €430.00
    Novus Biologicals Inc.
+1 additional image
 
ARP30213_P050

RGS4 antibody

RGS4 Rabbit Aff - Purified Bov, Can, Hu, Ms, Rb, Rt WB
50 µg / €330.00
    AVIVA Systems Biology
 
NB300-355

RGS5 antibody

Western Blot: E coli-derived fusion protein as test antigen. Affi-pure IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. ( anti-RGS5 ) Chicken Aff - Purified Hu, Ms, Rt WB
50 µg / €430.00
    Novus Biologicals Inc.
+1 additional image
 
SP7160P

RGS6 antibody

Western blot analysis of RGS6 in 30 ugs of mouse brain tissue lysate using SP7160P at 1:1000 dilution. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €310.00
    Acris Antibodies GmbH
 
NB100-56659

RGS6 antibody

Western Blot: RGS6 Antibody [NB100-56659] - Western blot analysis of RGS6 in 30 ugs of mouse brain tissue lysate using NB100-56659 at 1:1000 dilution. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €370.00
  IgG   Novus Biologicals Inc.
 
NB120-14070

RGS6 antibody

Linear Protein Map with Immunogenic Epitope Marked Chicken Aff - Purified Hu, Ms, Rt ICC/IF, WB
50 µg / €460.00
    Novus Biologicals Inc.
+1 additional image
 
ARP34043_P050

RGS6 antibody

RGS6 Rabbit Aff - Purified African clawed frog, Can, Chk, Hu, Ms, Rt, Ze P, WB
50 µg / €330.00
    AVIVA Systems Biology
+1 additional image
 
ARP42839_T100

RGS7 antibody

RGS7 Rabbit Aff - Purified Bov, Hu, Ms, Rt WB
0.1 mg / €290.00
    AVIVA Systems Biology
 
ARP42803_T100

RGS8 antibody

RGS8 Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.1 mg / €290.00
    AVIVA Systems Biology
 
SM5040P

RGS9 antibody

RGS9 Mouse D7 Purified Bov, Ms ICC/IF, IP, WB
0.1 mg / €330.00
  IgG1   Acris Antibodies GmbH
 

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