SP5352P KCNQ2 antibody

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0.1 mg / €330.00
Delivery Time: 7-10 working days

Quick Overview

Rabbit anti Human, Mouse, Rat KCNQ2

SP5352P

Product Description for KCNQ2

Rabbit anti Human, Mouse, Rat KCNQ2.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence.

Properties for KCNQ2

Product Category Antibodies
Quantity 0.1 mg
Synonyms KQT-like 2, KvLQT2, Neuroblastoma-specific potassium channel subunit alpha KvLQT2, Potassium voltage-gated channel subfamily KQT member 2, Voltage-gated potassium channel subunit Kv7.2
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications C, ICC/IF
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
O43526
Immunogen:
GST fusion protein encoding the first 70 amino acids of human KCNQ2.
Genename:
3785
Remarks:
SP5352P immunogen is a GST fusion protein encoding the first 70 amino acids of human KCNQ2.
Antibody type Ab
Application Immunocytochemistry: 0.5 µg/ml.
Immunohistochemistry on frozen sections: 0.5 µg/ml, staining of rat hippocampal using SP5352P yielded a strong signal in granule cell layer and the mossy fibers found in the central hilus of the dentate gyrus.
Immunofluorescence: 0.5 µg/ml.
Western Blot.
Background KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system and KNCQ2 and 3 have demonstrated their importance in M-current activation.
Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.
Concentration 1.0 mg/ml
General Readings
  • J. Cell Sci., Mar 2007; 120: 953-963.
  • British J. Pharm., 137:1173-1186, 2002.
Storage Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Epitope affinity chromatography.
Buffer System:
PBS containing 1 mg/ml BSA as stabilizer and 0.02% sodium azide as preservative.
State:
Liquid purified IgG fraction.
Aff - Purified
Specificity
Specificity:
SP5352P detects KCNQ2 from mouse, human and rat samples. This antibody is specific for KCNQ2 and does not detect KCNQ1, KCNQ3, KCNQ4 or KCNQ5.
Gene ID 3785
Targets

Accessory Products

Proteins and/or Positive Controls

Proteins for KCNQ2 (2 products)

Catalog No. Species Pres. Purity   Source  
H00003785-P01-10

KCNQ2

KCNQ2 Human in vitro transl.
10 µg / €350.00
  Abnova Taiwan Corp.
H00003785-P01-25

KCNQ2

KCNQ2 Human in vitro transl.
25 µg / €500.00
  Abnova Taiwan Corp.

Positive controls for KCNQ2 (1 products)

Catalog No. Species Pres. Purity   Source  
H00003785-T01

KCNQ2 Lysate(Denatured)

KCNQ2 Lysate(Denatured)
0.1 ml / €240.00
  Abnova Taiwan Corp.