Product Description for Chk2 Lysate
Product is tested for Western blot / Immunoblot.
Properties for Chk2 Lysate
| Product Category | Lysates |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53 |
| Shipping to | Not USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | Novus Biologicals Inc. |
Datasheet Extract
| Add. information | This product is manufactured by and sold under license from OriGene Technologies and its use is limited solely for research purposes. Research Areas: Stem Cell Markers, DNA Repair, Cancer |
|---|---|
| Application | Western Blot, This product is intended for use as a positive control in Western Blot., Western Blot |
| Background | In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Concentration | 1 mg/ml |
| Storage | Store at -20C. Avoid freeze-thaw cycles. |
| Targets |
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